Regulatory effect of 3'-tRF-PheGAA on Ang Ⅱ-induced cardiomyocyte hypertrophy and its mechanism [PDF]
精准医学杂志Objective To investigate the regulatory effect of 3'-tRF-PheGAA on angiotensin Ⅱ (Ang Ⅱ)-induced cardiomyocyte hypertrophy and its mechanism. Methods Primary cardiomyocytes of neonatal mice were obtained and cultured for 24 h, and were then divided into ...
CHENG Xueli, WANG Kai, ZHAO Yan, WANG Kun
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Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation. [PDF]
PLoS ONE, 2015 The human antigen R (HuR) stabilizes many mRNAs of proto-oncogene, transcription factors, cytokines and growth factors by recognizing AU-rich elements (AREs) presented in their 3' or 5' untranslated region (UTR).
Zhonghua Wang +2 more
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Pathogens, 2022 The compartmentalization of untranslated mRNA molecules in granules occurring in many eukaryotic organisms including trypanosomatids involves the formation of complexes between mRNA molecules and RNA-binding proteins (RBPs).
Ana Alonso +6 more
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BMC Cardiovascular Disorders, 2021 Background As the most frequent type of cyanotic congenital heart disease (CHD), tetralogy of Fallot (TOF) has a relatively poor prognosis without corrective surgery.
Haifei Yu, Xinrui Wang, Hua Cao
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West Nile virus encodes a microRNA-like small RNA in the 3' untranslated region which up-regulates GATA4 mRNA and facilitates virus replication in mosquito cells [PDF]
Nucleic Acids Research, 2011 West Nile virus (WNV) belongs to a group of medically important single-stranded, positive-sense RNA viruses causing deadly disease outbreaks around the world. The 3' untranslated region (3'-UTR) of the flavivirus genome, in particular the terminal 3' stem-loop (3'SL) fulfils multiple functions in virus replication and virus-host interactions. Using the
Hussain, M. +7 more
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Staufen Negatively Modulates MicroRNA Activity in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2016 The double-stranded RNA-binding protein Staufen has been implicated in various posttranscriptional gene regulatory processes. Here, we demonstrate that the Caenorhabditis elegans homolog of Staufen, STAU-1, functionally interacts with microRNAs.
Zhiji Ren +3 more
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Euchromatic transposon insertions trigger production of novel Pi- and endo-siRNAs at the target sites in the drosophila germline. [PDF]
PLoS Genetics, 2014 The control of transposable element (TE) activity in germ cells provides genome integrity over generations. A distinct small RNA-mediated pathway utilizing Piwi-interacting RNAs (piRNAs) suppresses TE expression in gonads of metazoans.
Sergey Shpiz +4 more
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Regulatory effect of 5'tRF-LysCTT on ferroptosis in mouse cardiomyocytes and its mechanism [PDF]
精准医学杂志Objective To investigate the regulatory effect of tRNA-derived small RNA (tsRNA) on ferroptosis in mouse cardiomyocytes and its mechanism. Methods RT-qPCR was used to measure the relative expression level of 5'tRF-LysCTT in the heart, liver, spleen ...
ZHAO Yan, WANG Kai, CHENG Xueli, WANG Kun
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PLoS Genetics, 2012 The epigenetic activity of transposable elements (TEs) can influence the regulation of genes; though, this regulation is confined to the genes, promoters, and enhancers that neighbor the TE.
Andrea D McCue +3 more
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Transcriptional Riboswitches Integrate Timescales for Bacterial Gene Expression Control
Frontiers in Molecular Biosciences, 2021 Transcriptional riboswitches involve RNA aptamers that are typically found in the 5′ untranslated regions (UTRs) of bacterial mRNAs and form alternative secondary structures upon binding to cognate ligands.
Catherine E. Scull +3 more
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