Results 91 to 100 of about 5,035,452 (301)

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Analysis of Mitochondrial Transfer RNA Mutations in Breast Cancer

Balkan Journal of Medical Genetics, 2022
Damage of mitochondrial functions caused by mitochondrial DNA (mtDNA) pathogenic mutations had long been proposed to be involved in breast carcinogenesis. However, the detailed pathological mechanism remained deeply undetermined.
Ding H.J., Zhao Y.P., Jiang Z.C., Zhou D.T., Zhu R.   +4 more
doaj   +1 more source

tRNA Profiling of Mesenchymal Stem Cell Exosome [PDF]

, 2018
Background: Exosomes have great potential in regenerative medicine through the transfer of their bioactive cargos, such as RNA. tRF RNA and tiRNA are tRNAderived non-coding RNA.
San, Khin MiMi
core   +1 more source

Role of noncoding RNA in vascular remodelling [PDF]

, 2016
Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling.
Baker, Andrew H., Bradshaw, Angela C., Deng, Lin   +2 more
core   +1 more source

Protein kinase FAM20C—when subcellular localization matters

FEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

Complete chloroplast genome sequence of Chrysosplenium ramosum and Chrysosplenium alternifolium (Saxifragaceae)

Mitochondrial DNA. Part B. Resources, 2020
The complete chloroplast genome of Chrysosplenium ramosum Maxim. and Chrysosplenium alternifolium L. were reported in this study. The chloroplast genomes were 153,460 bp for C. ramosum and 152,619 bp for C. alternifolium.
Wen-jie Yan, Hong Liu, Tian-ge Yang, Rui Liao, Rui Qin   +4 more
doaj   +1 more source

Free Extracellular miRNA Functionally Targets Cells by Transfecting Exosomes from Their Companion Cells. [PDF]

PLoS ONE, 2015
Lymph node and spleen cells of mice doubly immunized by epicutaneous and intravenous hapten application produce a suppressive component that inhibits the action of the effector T cells that mediate contact sensitivity reactions.
Krzysztof Bryniarski, Wlodzimierz Ptak, Emilia Martin, Katarzyna Nazimek, Marian Szczepanik, Marek Sanak, Philip W Askenase   +6 more
doaj   +1 more source

Introduction and Expression of a Rabbit β-globin Gene in Mouse Fibroblasts [PDF]

, 1979
The cloned chromosomal rabbit ß-globin gene has been introduced into mouse fibroblasts by DNA-mediated gene transfer (transformation). In this report, we examine the expression of the rabbit gene in six independent transformants that contain from 1 to 20
Axel, R., Lacy, E., Maniatis, T., Silverstein, S., Wigler, M., Wold, B.   +5 more
core  

Microguards and micromessengers of the genome [PDF]

, 2016
The regulation of gene expression is of fundamental importance to maintain organismal function and integrity and requires a multifaceted and highly ordered sequence of events.
A Bobrie, A Gioti, A Leiblich, A Lukasik, A Sharma, A Weiberg, AE Hall, AH Buck, B-C Yoo, C Braicu, C Fricke, D Green, D Haig, D Kim, DJ Sharkey, DM Pegtel, DP Bartel, E Marin-Gonzalez, E Tili, G Arnqvist, GL Hager, H Liu, H Valadi, H Zhou, J Lotvall, J Skog, JA Andres, JM Perkel, JR Chevillet, JS Parent, K Ohshima, K Sun, K Wang, L Corrigan, L Vojtech, LA McGraw, LA McGraw, LK Sirot, M Ghildiyal, M Greaves, M Mittelbrunn, MK Lawniczak, ML Squadrito, NS Barteneva, O Rechavi, P Cayirlioglu, P Kumar, P Xu, PB Medawar, PS Mitchell, S Mathivanan, S Sarker, S Weilner, S Wigby, S Wigby, T Chapman, T Chapman, T Chapman, T Chapman, T Chapman, T Dalmay, T Dalmay, T Kogure, TE Swingler, VN Kim, W Filipowicz, WX Chen, X Chen, Y Lee, Y Ouyang   +69 more
core   +1 more source

Extracellular vesicle-mediated transfer of functional RNA in the tumor microenvironment

Oncoimmunology, 2015
Extracellular vesicles (EVs) have been shown to transfer various molecules, including functional RNA between cells and this process has been suggested to be particularly relevant in tumor-host interactions.
K. Ridder, A. Sevko, Janina Heide, M. Dams, Anne-Kathleen Rupp, J. Macas, J. Starmann, M. Tjwa, K. Plate, H. Sültmann, P. Altevogt, V. Umansky, S. Momma   +12 more
semanticscholar   +1 more source