Results 111 to 120 of about 4,943,496 (345)

Complete mitochondrial genome of the coconut black-headed caterpillar Opisina arenosella (Lepidoptera: Gelechioidea: Xyloryctidae)

open access: yesMitochondrial DNA. Part B. Resources, 2019
In the present study, we determined the complete mitogenome of Opisina arenosella, the first for the family Xyloryctidae. This mitochondrial genome contains 15,389 bp, with an A + T content of 80.5% and consists of 13 protein-coding genes, 22 transfer ...
Rui Meng, Yao He, Su Ao, Bo Cai
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

Analysis of tRNA halves (tsRNAs) in serum from cattle challenged with bovine viral diarrhea virus

open access: yesGenetics and Molecular Biology
Acute infections of bovine viral diarrhea virus (BVDV) lead to a range of clinical presentations. Laboratory tests for detection depend on collection of samples during a short viremia. Acutely infected animals remain largely undiagnosed.
Tasia M. Taxis   +3 more
doaj   +1 more source

Efficient and quantitative high-throughput transfer RNA sequencing

open access: yesNature Methods, 2015
Despite its biological importance, tRNA has not been adequately sequenced by standard methods because of its abundant post-transcriptional modifications and stable structure, which interfere with cDNA synthesis.
G. Zheng   +7 more
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

What's in your next-generation sequence data? An exploration of unmapped DNA and RNA sequence reads from the bovine reference individual. [PDF]

open access: yes, 2015
BackgroundNext-generation sequencing projects commonly commence by aligning reads to a reference genome assembly. While improvements in alignment algorithms and computational hardware have greatly enhanced the efficiency and accuracy of alignments, a ...
Alexander, Leeson J   +9 more
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Charging State Analysis of Transfer RNA from an α-proteobacterium

open access: yesBio-Protocol, 2020
Transfer RNA (tRNA) is an essential link between the genetic code and proteins. During the process of translation, tRNA is charged with its cognate amino acid and delivers it to the ribosome, thus serving as a substrate of protein synthesis.
Liang Yin, Caroline Harwood
doaj   +1 more source

Extracellular vesicle-mediated transfer of processed and functional RNY5 RNA

open access: yesRNA: A publication of the RNA Society, 2015
Extracellular vesicles (EVs) have been proposed as a means to promote intercellular communication. We show that when human primary cells are exposed to cancer cell EVs, rapid cell death of the primary cells is observed, while cancer cells treated with ...
S. Chakrabortty   +4 more
semanticscholar   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

open access: yes
FEBS Letters, EarlyView.
Igor Zivkovic   +2 more
wiley   +1 more source

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