Results 121 to 130 of about 4,960,505 (304)

The Gametic Synapse: RNA Transfer to the Bovine Oocyte1

Biology of Reproduction, 2014
A. Macaulay, I. Gilbert, J. Caballero, R. Barreto, É. Fournier, Prudencio Tossou, M. Sirard, H. Clarke, É. W. Khandjian, F. Richard, P. Hyttel, C. Robert   +11 more
semanticscholar   +1 more source

Transfer RNA

FEBS Letters, 2009
Ibba, Michael, Santos, Manuel A.S.
openaire   +1 more source

The Conformation of Transfer RNA

Kobunshi, 1972
一定の塩基配列で規定される転移リボ核酸(tRNA)は鎖内部での特異的塩基対形成によってクローバー葉形の二次構造をとる。三次元的にはクローバー葉構造が折りたたまれて高次構造を形成するが,その存在は主として熱変性過程の研究から明らかになった。t RNAのコンホメーションの安定化には陽イオン,とりわけ二価金属イオンが大きな効果を示す。Mg++,Mn++,Co++などはtRNAに約20～30個特異的に結合し,その会合定数は103～104の大きさである。ある種のtRNAには生物活性形と変性形が見出され,相互変換には二価イオンが決定的な役割を果す。活性形は約2～3個の二価イオン部位をよけいにもち,変換にはリン酸基の中和を伴うコンホメーション変化が起こると考えられる ...
openaire   +3 more sources

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

On the conformation of transfer RNA. [PDF]

Proceedings of the National Academy of Sciences, 1968
F, Cramer, H, Doepner, V D, Haar F, E, Schlimme, H, Seidel   +4 more
openaire   +3 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Structural signatures of thermal adaptation of bacterial ribosomal RNA, transfer RNA, and messenger RNA. [PDF]

PLoS One, 2017
Jegousse C, Yang Y, Zhan J, Wang J, Zhou Y.   +4 more
europepmc   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Trans-kingdom small RNA transfer during host-pathogen interactions: The case of P. falciparum and erythrocytes. [PDF]

RNA Biol, 2017
Walzer KA, Chi JT.
europepmc   +1 more source