Results 171 to 180 of about 538,895 (285)

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source

Effects of environmental salinity on global and endocrine-specific transcriptomic profiles in the caudal neurosecretory system of salmonid fishes. [PDF]

FASEB J
Culbert BM, McCormick SD, Bernier NJ.
europepmc   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Integrated Co-extraction Protocol for Transcriptomic and H NMR Metabolomic Analysis of Multi-species Biofilms. [PDF]

Bio Protoc
Séguéla A, Della-Negra O, Gautier R, Hamelin J, Milferstedt K, Servien R, Teste MA, Canlet C.   +7 more
europepmc   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

Simple Method for Efficient RNA Extraction From Arabidopsis Embryos. [PDF]

Bio Protoc
Marchetti F, Pagnussat G, Zabaleta E.
europepmc   +1 more source

Regulating Protein Immobilization During Cell‐Free Protein Synthesis in Hyaluronan Microgels

Advanced Biology, EarlyView.
Bifunctional microgels carrying a linear DNA template and Ni2+‐activated NTA moieties are used as platform for cell‐free protein synthesis and in situ protein immobilization. By varying the concentration of NTA moieties in the microgels, the amount of GFP‐His immobilized inside the microgel and released to the microgel environment can be regulated ...
Anika Kaufmann, Kateryna Ivanova, Julian Thiele   +2 more
wiley   +1 more source

Engineered mitochondria in diseases: mechanisms, strategies, and applications. [PDF]

Signal Transduct Target Ther
Li M, Wu L, Si H, Wu Y, Liu Y, Zeng Y, Shen B.   +6 more
europepmc   +1 more source

Toward Design Principles for Biomolecular Condensates for Metabolic Pathways

Advanced Biology, EarlyView.
Biomolecular condensates are membrane‐less compartments found through‐out nature which can serve as reaction crucibles for biochemical processes. This review explores the design strategies underlying how condensates can be used in biotechnology to enhance multistep enzyme cascades including enhancement by mass action and substrate channeling, and ...
Alain A.M. André, Nikita Rehnberg, Ankush Garg, Magnus Kjærgaard   +3 more
wiley   +1 more source

The role of CsrA in controls the extracellular electron transfer and biofilm production in <i>Geobacter sulfurreducens</i>. [PDF]

Front Microbiol
Hernández-Eligio A, Vega-Alvarado L, Liu X, Cholula-Calixto J, Huerta-Miranda G, Juárez K.   +5 more
europepmc   +1 more source