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Advanced Science, EarlyView.Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li +13 more
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Viral sensing by RNA helicases
Virologie, 2020A key aspect of antiviral immunity is the distinction between "self" and "non-self" components. This distinction can be established through the detection of double-stranded RNA (dsRNA), a common sign of viral infection, by cytosolic RNA helicases.
Claire, Rousseau, Carine, Meignin
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Critical Reviews in Biochemistry, 1988
Recent progress in molecular biological techniques revealed that genomes of animal viruses are complex in structure, for example, with respect to the chemical nature (DNA or RNA), strandedness (double or single), genetic sense (positive or negative), circularity (circle or linear), and so on.
A, Ishihama, K, Nagata
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Recent progress in molecular biological techniques revealed that genomes of animal viruses are complex in structure, for example, with respect to the chemical nature (DNA or RNA), strandedness (double or single), genetic sense (positive or negative), circularity (circle or linear), and so on.
A, Ishihama, K, Nagata
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RNA Editing with Viral RNA-Dependent RNA Polymerase
ACS Synthetic Biology, 2022RNA editing is currently attracting attention as a method for editing genetic information without injury to the genome. The most common approach to edit RNA sequences involves the induction of an A-to-I change by adenosine deaminase acting on RNA (ADAR). However, this method only allows point editing.
Shinzi Ogasawara, Ai Yamada
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Viral suppressors of RNA silencing
Trends in Plant Science, 2011The infection and replication of viruses in the host induce diverse mechanisms for combating viral infection. One of the best-studied antiviral defence mechanisms is based on RNA silencing. Consistently, several viral suppressors of RNA silencing (VSRs) have been identified from almost all plant virus genera, which are surprisingly diverse within and ...
József, Burgyán, Zoltán, Havelda
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Viral suppressors of RNA silencing
Current Opinion in Biotechnology, 2001The suppression of RNA silencing by plant viruses represents a viral adaptation to a novel host antiviral defense. Three types of viral suppressors have been identified through the use of a variety of silencing suppression assays. The first two types of suppressor are capable of a complete or partial reversal of pre-existing RNA silencing; the third ...
W X, Li, S W, Ding
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Nature Microbiology, 2020
N6-methyladenosine (m6A) is a widespread modifcation on cellular RNA that is dynamically regulated involving m6A writers, erasers and readers, and can impact many cellular processes and pathways.
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N6-methyladenosine (m6A) is a widespread modifcation on cellular RNA that is dynamically regulated involving m6A writers, erasers and readers, and can impact many cellular processes and pathways.
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Virology, 1974
Abstract Influenza viral messenger RNA (mRNA) free from both ribosomal RNA and newly synthesized host mRNA was isolated from the polyribosomes of infected canine kidney cells. Cordycepin was added to infected cells to inhibit ribosomal RNA and host mRNA synthesis.
P R, Etkind, R M, Krug
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Abstract Influenza viral messenger RNA (mRNA) free from both ribosomal RNA and newly synthesized host mRNA was isolated from the polyribosomes of infected canine kidney cells. Cordycepin was added to infected cells to inhibit ribosomal RNA and host mRNA synthesis.
P R, Etkind, R M, Krug
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Studies in the replication of viral RNA
Journal of Cellular Physiology, 1967Experiments will be described which demonstrate that the product of purified “Qβ-replicase” is fully competent to serve both as a template and as a program for the synthesis of complete virus particles. The use of mutant RNA has permitted the demonstration that nucleic acid is the instructive agent in the replication process and hence satisfies the ...
S, Spiegelman +6 more
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Physics of RNA and viral assembly
The European Physical Journal E, 2006The overview discusses the application of physical arguments to structure and function of single-stranded viral RNA genomes.
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