Results 201 to 210 of about 987,281 (377)
Advanced Healthcare Materials, EarlyView.This study develops a 3D vascular injury model using a microphysiological system that mimics key features of intimal hyperplasia. Antiproliferative drugs reduced VSMC proliferation but worsened endothelialdenudation. A combination of diphenyleneiodonium and quercetin effectively reduced proliferation and migration of VSMC and inflammation while ...
Ungsig Nam +7 more
wiley +1 more source
Characterization of an Endogenous RNA-Dependent DNA Polymerase Associated with Murine Intracisternal A Particles [PDF]
, 1974 Stringner S. Yang, Nelson A. Wivel
openalex +1 more source
RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19
Biochemical and Biophysical Research Communications - BBRC, 2020 Yi Jiang, W. Yin, H. E. Xu
semanticscholar +1 more source
Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo
Advanced Healthcare Materials, EarlyView.This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla +16 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex +4 more
wiley +1 more source
Template Specificity of Eucaryotic DNA‐Dependent RNA Polymerases [PDF]
, 1974 Sarah Jane Flint +3 more
openalex +1 more source
Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery
Advanced Healthcare Materials, EarlyView.Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang +6 more
wiley +1 more source
On the Initiation of Transcription by DNA‐Dependent RNA Polymerase from Escherichia coli [PDF]
, 1973 Rolf Schäfer +3 more
openalex +1 more source