Results 201 to 210 of about 1,029,988 (373)

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

Antiviral Research, 2019
Ariane J. Brown, John J. Won, Rachel L. Graham, K. Dinnon, A. Sims, Joy Y. Feng, T. Cihlář, M. Denison, R. Baric, T. Sheahan   +9 more
semanticscholar   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Covalent Small Ubiquitin-like Modifier (SUMO) Modification of Maf1 Protein Controls RNA Polymerase III-dependent Transcription Repression [PDF]

, 2013
Aarti D. Rohira, Chun-Yuan Chen, Justin R. Allen, Deborah L. Johnson   +3 more
openalex   +1 more source

Viral RNA-dependent RNA polymerase [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

PTEN Represses RNA Polymerase III-Dependent Transcription by Targeting the TFIIIB Complex

, 2008
Annette Woiwode, Sandra Johnson, Shuping Zhong, Cheng Zhang, Robert G. Roeder, Martin Teichmann, Deborah L. Johnson   +6 more
openalex   +1 more source

Nucleocytoplasmic shuttling of the West Nile virus RNA ‐dependent RNA polymerase NS5 is critical to infection [PDF]

, 2018
Adam J. López‐Denman, Alice Russo, Kylie M. Wagstaff, Peter A. White, David A. Jans, Jason M. Mackenzie   +5 more
openalex   +1 more source

Supplementary Figure 2 from Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II [PDF]

, 2023
Stefano Giustino Manzo, Zhaoli Zhou, Ying-Qing Wang, Jessica Marinello, Qingli He, Yuanchao Li, Jian Ding, Giovanni Capranico, Ze‐Hong Miao   +8 more
openalex   +1 more source

Bacteriophage φ6 RNA-dependent RNA Polymerase [PDF]

Journal of Biological Chemistry, 2002
Minni R.L. Laurila, Eugene V. Makeyev, Dennis H. Bamford   +2 more
openaire   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source