Results 271 to 280 of about 867,422 (305)
Some of the next articles are maybe not open access.
Sequence Design for RNA-RNA Interactions
The design of RNA sequences with desired structural properties presents a challenging computational problem with promising applications in biotechnology and biomedicine. Most regulatory RNAs function by forming RNA-RNA interactions, e.g., in order to regulate mRNA expression.Maria Waldl +2 more
openaire +2 more sources
Computational Prediction of RNA–RNA Interactions
2013We describe different tools and approaches for RNA-RNA interaction prediction. Recognition of ncRNA targets is predominantly governed by two principles, namely the stability of the duplex between the two interacting RNAs and the internal structure of both mRNA and ncRNA. Thus, approaches can be distinguished into different major categories depending on
openaire +3 more sources
RNA-RNA interactions between oligonucleotide substrates for aminoacylation
Bioorganic & Medicinal Chemistry, 1997RNA stem-loop microhelices with helix sequences based on tRNA acceptor stems can be charged with specific amino acids. Experiments were designed to test the possibility that microhelices could laterally associate through complementary loop sequences and thereby bring their attached aminoacyl groups close enough together to form a peptide bond. Computer
B S, Henderson, P, Schimmel
openaire +2 more sources
Technological advancements in deciphering RNA-RNA interactions
Molecular CellRNA-RNA interactions (RRIs) can dictate RNA molecules to form intricate higher-order structures and bind their RNA substrates in diverse biological processes. To elucidate the function, binding specificity, and regulatory mechanisms of various RNA molecules, especially the vast repertoire of non-coding RNAs, advanced technologies and methods that ...
Rong Ye +3 more
openaire +2 more sources
Investigation of RNA‐RNA Interactions Using the RISE Database
Current Protocols in Bioinformatics, 2018AbstractRNA‐RNA interactions (RRIs) are essential to understanding the regulatory mechanisms of RNAs. Mapping RRIs in vivo in a transcriptome‐wide manner remained challenging until the recent development of several sequencing‐based technologies. However, RRIs generated from large‐scale studies had not been systematically collected and analyzed before ...
Yanyan, Ju +3 more
openaire +2 more sources
RNA–RNA Interaction Prediction and Antisense RNA Target Search
Journal of Computational Biology, 2005Recent studies demonstrating the existence of special noncoding "antisense" RNAs used in post transcriptional gene regulation have received considerable attention. These RNAs are synthesized naturally to control gene expression in C. elegans, Drosophila, and other organisms; they are known to regulate plasmid copy numbers in E. coli as well. Small RNAs
Can Alkan +4 more
openaire +2 more sources
Detecting RNA–RNA Interactions Using Psoralen Derivatives
Cold Spring Harbor Protocols, 2014Psoralens are tricyclic compounds that intercalate into double-stranded DNA or RNA and, on irradiation with long-wavelength (365-nm) UV light, covalently link pyrimidines on adjacent strands. More rarely, psoralen cross-links can be observed at the ends of helices (i.e., double-stranded–single-stranded boundaries).
openaire +2 more sources
RNA-RNA interaction and gene splicing.
Cancer biochemistry biophysics, 1997The precise excision of intervening sequences during RNA splicing is an interesting example of the high degree of specificity involved in biosynthesis processes. Self-splicing RNA precursors achieve this specificity primarily through intramolecular interactions whereas all other types of RNA splicing requires interaction between cellular factors and ...
M, Verma +3 more
openaire +1 more source
RNA-RNA interactions in mammalian genomes
2019RNA-splicing by the spliceosome is an important characteristic of eukaryotic organisms and the foundation of protein diversity and synthesis in humans. During the splicing process introns are removed from the coding sequences to yield a mature RNA transcript that can be further translated to proteins.
openaire +1 more source
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
Cell, 2021Ryan A Flynn +2 more
exaly