Results 101 to 110 of about 591,228 (346)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CleanUpRNAseq: An R/Bioconductor Package for Detecting and Correcting DNA Contamination in RNA-Seq Data

BioTech
RNA sequencing (RNA-seq) has become a standard method for profiling gene expression, yet genomic DNA (gDNA) contamination carried over to the sequencing library poses a significant challenge to data integrity.
Haibo Liu, Kai Hu, Kevin O’Connor, Michelle A. Kelliher, Lihua Julie Zhu   +4 more
doaj   +1 more source

The Comparison between Bulk RNA-seq and Ssingle-cell RNA-seq

Journal of Physics: Conference Series, 2021
Abstract Bulk RNA-seq and single cell RNA-seq (Sc-RNA) seq are two well-known methods and are broadly used in biology areas. Even though the two ways are all starting from the mRNA level to do the transcriptional analysis, many differences still show in them, but the differences which are critical for researchers to judge and consider ...
openaire   +1 more source

Utilizing RNA-Seq Data for Cancer Network Inference

, 2012
An important challenge in cancer systems biology is to uncover the complex network of interactions between genes (tumor suppressor genes and oncogenes) implicated in cancer. Next generation sequencing provides unparalleled ability to probe the expression
Atwal, Gurinder S., Cai, Ying, Fendler, Bernard   +2 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

RNA-Seq Analysis Illuminates the Early Stages of Plasmodium Liver Infection [PDF]

, 2020
Maria Toro-Moreno, Kayla Sylvester, Tamanna Srivastava, Dora Posfai, Emily R. Derbyshire   +4 more
openalex   +1 more source

RNA-Seq Illumina

, 2020
RNA-Seq with ...
openaire   +1 more source

P5424 RNA-seq tutorial datasets

, 2022
A set of RNA-seq datasets obtained from P5424 cell line stimulated or not with PMA  and Ionomycin. Reads are limited to those that map on chr18 (20M to 50M).
openaire   +1 more source

Barcode, UMI, Set format and BUStools [PDF]

, 2019
We introduce the Barcode-UMI-Set format (BUS) for representing pseudoalignments of reads from single-cell RNA-seq experiments. The format can be used with all single-cell RNA-seq technologies, and we show that BUS files can be efficiently generated ...
Melsted, Páll, Ntranos, Vasilis, Pachter, Lior   +2 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source