Results 231 to 240 of about 591,228 (346)

RNA-Seq of Cultured Peripheral Blood Lymphocytes Improves Identification of Cryptic Splicing Defects in Rare Disease Diagnostics. [PDF]

Hum Mutat
Ren J, Dai C, Meng F, Zhang P, Xie C, Xiao W, He W, Yuan S, Li X, Zhang Q, Tang W, Hu L, Chen Z, Lu G, Du J, Zeng S, Lin G.   +16 more
europepmc   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Expression changes in Fasl-deficient calvaria-derived osteoblasts: an RNA-seq analysis. [PDF]

Sci Data
Kratochvilova A, Zapletalova M, Gruber R, Janeckova E, Kytkova L, Matalova E.   +5 more
europepmc   +1 more source

RNA-seq analysis of VEGF-induced STAT3 in human retinal microvascular cells

, 2020
Aniket Ramshekar, Colin A. Bretz, M. Elizabeth Hartnett   +2 more
openalex   +1 more source

Pre‐Administration of Akkermansia Muciniphila Prevents the Development of Severe Acute Graft‐Versus‐Host Disease in Systemic Organs

Advanced Science, EarlyView.
Akkermansia muciniphila, a next‐generation probiotic, alleviates acute graft‐versus‐host disease (aGvHD) following allogeneic hematopoietic stem cell transplantation (HSCT) by providing protective effects across multiple organs. Pre‐colonization with A.
Jeong‐Eun Han, Dae‐Seong Lee, Su‐Won Jeong, Ji‐Hyun Yun, Seomin Kang, Seoyoung Jang, EunAh Lee, Ju Hye Baek, Che Ok Jeon, Jin‐Woo Bae   +9 more
wiley   +1 more source

Machine Learning Models for Cancer Research: A Narrative Review of Bulk RNA-Seq Applications. [PDF]

Int J Mol Sci
Pudova EA, Pavlov VS, Guvatova ZG, Fedorova MS, Shegai PV, Kudryavtseva AV, Snezhkina AV.   +6 more
europepmc   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

Utilisation of Machine Learning Approaches Improves RNA-Seq Transcriptome Analyses in Alzheimer's Disease Brain. [PDF]

J Mol Neurosci
Cheng Y, Santucci K, Gao Y, Takenaka K, Lindner G, Xu SM, Janitz M.   +6 more
europepmc   +1 more source

Single‐Cell RNA Sequencing of Retina Reveals Nna1 Upregulation in Myopic Diabetic Retinopathy as a Protective Factor Against Diabetic Damage

Advanced Science, EarlyView.
This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie, Yingjun Cai, Bolin Chen, Bowen Li, Jing Zou, Huizhuo Xu   +5 more
wiley   +1 more source

MntJULiP and Jutils: differential splicing analysis of RNA-seq data with covariates. [PDF]

NAR Genom Bioinform
Lui WW, Yang G, He Z, Florea L.
europepmc   +1 more source