Development of a rapid and modified total RNA extraction method from polyphenolic-rich <i>Gossypium hirsutum</i>. [PDF]
MethodsXGul A, Rao AQ, Bakhsh A.
europepmc +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Novel Long Non-coding RNA Markers for Prognostic Prediction of Patients with Bladder Cancer [PDF]
, 2020 LI Wen-xing, Zhang Yanli
openalex +1 more source
Gamma-FIT-PNAs as sensitive RNA probes. [PDF]
RSC Chem BiolGupta MK, Maree S, Yavin E.
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Regulation of RNA methylation linked to drug resistance in gastric cancer. [PDF]
Front Cell Dev BiolYang Z, Ma Y, Xu Z, Liu H, Gu X, Sun J.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Characterization and engineering of sequences controlling in vivo synthesis of brome mosaic virus subgenomic RNA [PDF]
, 1988 R. French, Paul Ahlquist
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Crystal structures of Caenorhabditis elegans PUF-3 depict plasticity of RNA recognition that enables germline gene regulation. [PDF]
Nucleic Acids ResZhang Y, Kennedy FD, Hall TMT.
europepmc +1 more source