Results 191 to 200 of about 2,455,342 (249)

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Targeted RNA Degradation as a Promising Therapeutic Strategy. [PDF]

Int J Mol Sci
Komachankandy S, Lee Y.
europepmc   +1 more source

A direct RNA-seq-based EBV Latency Transcriptome Offers Insights into the Biogenesis of EBV Gene Products [PDF]

Aaron Mamane-Logsdon, Isabelle Zane, Chong See Chong, Oscar Hou In Chou, Mahesh Rawal, Adam C. T. Gillman, Wiyada Wongwiwat, I’ah Donovan-Banfield, David A. Matthews, Robert E. White   +9 more
openalex   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Coupling of polymerase-nucleoprotein-RNA in an influenza virus mini ribonucleoprotein complex. [PDF]

Nat Commun
Kang H, Yang Y, Liu Y, Li M, Zhang L, Lin Y, Witte L, Chen KY, Song W, Xu Z, He X, Guddat LW, Guo Y, Yan L, Gao Y, Fodor E, Rao Z, Lou Z.   +17 more
europepmc   +1 more source

Landscape of A-I RNA editing in mouse, pig, macaque, and human brains [PDF]

Conghui Li, Wei Lv, Zhiwei He, Xiaoguang Pan, Yuchen Zeng, Jan Mulder, Evelina Sjöstedt, Zhiwei Huang, Wei Liu, Liangzhi Xu, Eli Eisenberg, Lin Lin, Jacob B. Hansen, Jinrong Huang, Yonglun Luo   +14 more
openalex   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Constrained reassortment and genotype-specific traits shape the evolutionary landscape of galbut virus. [PDF]

Virus Evol
Keene-Snickers AH, Brehm AL, Dunham TJ, Gelpi TA, Stenglein MD.   +4 more
europepmc   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source