Results 201 to 210 of about 2,497,031 (299)

Accurate detection of somatic single-nucleotide variants from bulk RNA-seq data using RNA-MosaicHunter. [PDF]

Nucleic Acids Res
Huang AY, Cheng Y, Ku J, Zhao B, Park J, Kim D, Choi J, Lee EA.   +7 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

New insights into the promoterless transcription of DNA coligo templates by RNA polymerase III [PDF]

, 2014
Lodoe Lama, Christine Seidl, Kevin Ryan
openalex   +1 more source

theRNA: a curated knowledgebase of functional RNA therapeutics spanning diverse modalities and disease applications. [PDF]

Nucleic Acids Res
Zhou Y, Hu Y, Zhang L, Wu T, Peng S, Lin C, Wang Z, Zhou Z, Zheng J, Ren J, Zuo Z.   +10 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

RNA‐Interference Approach to Study Functions of NADPH : Cytochrome P450 Oxidoreductase in Human Hepatocytes [PDF]

, 2009
Diana M. Feidt, Kathrin Klein, Andreas K. Nüssler, Ulrich M. Zanger   +3 more
openalex   +1 more source

Evaluation of RNA extraction and rRNA depletion protocols for RNA-Seq in eleven edible seaweed species from brown, red, and green algae. [PDF]

PLoS One
Dekker RJ, Ensink WA, van Olst MF, van Leeuwen SM, de Leeuw WC, Jonker MJ, Breit TM.   +6 more
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Identification of lung adenocarcinoma-specific exosome RNAs in peripheral blood by RNA-Seq analysis.

, 2020
Liu Xq, Amanda Tufman, Rosemarie Kiefl, Li Gf, Ma Ql, Huber Rm   +5 more
openalex   +2 more sources

There is a world beyond protein mutations: the role of non‐coding RNAs in melanomagenesis [PDF]

, 2013
Rolf Swoboda, Meenhard Herlyn
openalex   +1 more source