Results 271 to 280 of about 2,322,564 (290)

Architecture of RNA–RNA interactions

Current Opinion in Genetics & Development, 2022
RNA molecules tend to form intricate tertiary structures via intramolecular RNA-RNA interactions (RRIs) to regulate transcription, RNA processing, and translation processes. In these biological processes, RNAs, especially noncoding RNAs, usually achieve their regulatory specificity through intermolecular RNA-RNA base pairing and execute their ...
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RNA–RNA Interaction Prediction and Antisense RNA Target Search

Journal of Computational Biology, 2005
Recent studies demonstrating the existence of special noncoding "antisense" RNAs used in post transcriptional gene regulation have received considerable attention. These RNAs are synthesized naturally to control gene expression in C. elegans, Drosophila, and other organisms; they are known to regulate plasmid copy numbers in E. coli as well. Small RNAs
Can, Alkan, Emre, Karakoç, Joseph H, Nadeau, S Cenk, Sahinalp, Kaizhong, Zhang   +4 more
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RNA–RNA SELEX

2014
Systematic evolution of ligands by exponential enrichment (SELEX) protocol is a valuable technique to identify RNA aptamers interacting with RNA structural motifs. RNA aptamers are mainly resolved with affinity column chromatography and electrophoretic mobility shift assay (EMSA).
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Picornavirus RNA-dependent RNA polymerase

The International Journal of Biochemistry & Cell Biology, 2009
Replication of the picornavirus genome is catalysed by a viral encoded RNA-dependent RNA polymerase, termed 3D polymerase. Together with other viral and host proteins, this enzyme performs its functions in the cytoplasm of host cells. The crystal structure of 3D polymerase from a number of picornaviruses has been determined.
Chee Choy, Kok, Peter C, McMinn
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RNA-Dependent RNA Polymerases, Viruses, and RNA Silencing

Science, 2002
Most viruses have RNA genomes that are replicated and transcribed into messenger RNA by viral RNA–dependent RNA polymerases (RdRps), usually in concert with other viral and host factors. Many, if not most, eukaryotes also encode putative RdRps that have been implicated in sequence-specific, RNA-triggered gene silencing.
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RNA Libraries and RNA Recognitiona

Annals of the New York Academy of Sciences, 1996
Random RNA libraries, consisting of > 10(13) unique sequences, contain molecules capable of specifically binding small molecule and protein ligands by noncovalent interaction. Successive steps of affinity purification and amplification allow the propagation and eventual isolation of specific binding molecules, called aptamers.
F J, Schmidt, B, Cho, H B, Nicholas
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Nanostructured RNAs for RNA Interference

2014
We synthesized three types of nanostructured RNAs that induce RNA interference (RNAi): branched RNAs, dumbbell-shaped RNA, and circular double-stranded RNAs. All three nanostructured RNAs were transformed into double-stranded RNA of approximately 20 base pairs when they were treated with nuclease enzymes such as Dicer.
Yuko, Nakashima, Naoko, Abe, Yoshihiro, Ito, Hiroshi, Abe   +3 more
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Analysis RNA-seq and Noncoding RNA

2016
RNA-Seq is an approach to transcriptome profiling that uses deep-sequencing technologies to detect and accurately quantify RNA molecules originating from a genome at a given moment in time. In recent years, the advent of RNA-Seq has facilitated genome-wide expression profiling, including the identification of novel and rare transcripts like noncoding ...
A. Arrigoni, V. Ranzani, G. Rossetti, I. Panzeri, S. Abrignani, R. J. P. Bonnal, M. Pagani   +6 more
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Predicting novel RNA–RNA interactions

Current Opinion in Structural Biology, 2008
The purpose of this article is to give a brief, yet concise overview of the current computational methods for predicting novel RNA-RNA interactions, that is interactions whose characteristic features we do not yet know. We start by briefly reviewing experimentally confirmed examples of RNA-RNA interactions before introducing computational methods for ...
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RNA-Based Drugs: From RNA Interference to Short Interfering RNAs

Current Pharmaceutical Biotechnology, 2004
RNA interference consists of a sequence specific post-transcriptional gene silencing phenomenon triggered by a double strand RNA molecule homologous to the silenced gene. The dsRNA is cleaved by DICER enzyme in small dsRNA pieces, named short interfering RNAs (siRNAs).
Poliseno L, Mercatanti A, Citti L, Rainaldi G   +3 more
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