Results 211 to 220 of about 331,295 (252)

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Nobel lecture. Enzymatic cleavage of RNA by RNA.

Bioscience reports, 1991
openaire   +1 more source

The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a [PDF]

Cell, 2017
Cas13a, a type VI-A CRISPR-Cas RNA-guided RNA ribonuclease, degrades invasive RNAs targeted by CRISPR RNA (crRNA) and has potential applications in RNA technology. To understand how Cas13a is activated to cleave RNA, we have determined the crystal structure of Leptotrichia buccalis (Lbu) Cas13a bound to crRNA and its target RNA, as well as the cryo-EM ...
Xueyan Li, Zongqiang Li, Jiuyu Wang
exaly   +3 more sources

Introduction to RNA/DNA Cleavage [PDF]

Chemical Reviews, 1998
James K Bashkin
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

Mechanisms of Ribozyme-Mediated RNA Cleavage

Chemical Reviews, 1998
Robert G Kuimelis, Larry W Mclaughlin
exaly   +3 more sources

RNA cleavage by small catalytic RNAs

Current Opinion in Structural Biology, 1995
Recent studies of the hammerhead ribozyme have provided an insight into its three-dimensional structure. In addition, studies using chemical probes, functional-group modification and mutational analysis, in combination with computer modelling, have led to proposals for the structure of both the hairpin and hepatitis delta virus ribozymes.
T, Tuschl, J B, Thomson, F, Eckstein
openaire   +2 more sources

Cleavage of RNA oligonucleotides by aminoglycosides

Org. Biomol. Chem., 2009
A number of aminoglycoside antibiotics, and in particular neomycin B, are demonstrated to promote strand cleavage of RNA oligonucleotides (minimised HIV-1 TAR element and prokaryotic ribosomal A-site), by binding and causing sufficient distortion to the RNA backbone to render it more susceptible to intramolecular transesterification.
Matthew J, Belousoff, Bim, Graham, Leone, Spiccia, Yitzhak, Tor   +3 more
openaire   +2 more sources

Synthetic metallonucleases for RNA cleavage

Current Opinion in Chemical Biology, 2004
Synthetic metallonucleases are versatile metal ion catalysts that use multiple catalytic strategies for the cleavage of RNA. Recent work in the design of more active metallonucleases combines a single metal ion with functional groups that interact with RNA, including amino acid fragments or additional metal ions.
Janet R, Morrow, Olga, Iranzo
openaire   +2 more sources

Enediyne-mediated cleavage of RNA

Bioorganic & Medicinal Chemistry, 1995
RNA cleavage by enediyne anticancer antibiotics was shown to occur with no apparent sequence selectivity, but RNA structure appears to be important in those substrates where cleavage was observed. Neocarzinostatin (NCS) cleaved a wider variety of RNA substrates than either esperamicin (ESP) or calicheamicin (CAL), and dynemicin (DYN) has yet to cleave ...
J M, Battigello, M, Cui, S, Roshong, B J, Carter   +3 more
openaire   +2 more sources