Results 221 to 230 of about 208,041 (335)

Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

Advanced Science, EarlyView.
This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang, Feifei Li, Libo Liu, Ziyu An, Hanzhong Luo, Huan Zhang, Rui Ma, Ruoxi Zhang, Qiong Dai, Mingduo Zhang, Jinfan Tian, Chaoyong Liu, Xiantao Song, Yunfeng Lu   +13 more
wiley   +1 more source

Regulation of maize growth and immunity by ZmSKI3-mediated RNA decay and post-transcriptional gene silencing. [PDF]

J Integr Plant Biol
Gao J, Zhang N, Liu G, Tian J, Chen M, Wang Y, Xing Y, Zhang Y, Zhao C, Mu X, Yu Y, Niu H, Li J, Tang J, Gou M.   +14 more
europepmc   +1 more source

RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters [PDF]

, 2020
Ella Hartenian, Sarah Gilbertson, Joel D. Federspiel, Ileana M. Cristea, Britt A. Glaunsinger   +4 more
openalex   +1 more source

SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks

Advanced Science, EarlyView.
SCRIPT is a novel method inferring single‐cell cis‐regulatory relationships (CRRs) from transcriptomic and chromatin accessibility data. SCRIPT incorporates two key innovations: graph causal attention networks supported by empirical CRR evidence, and representation learning enhanced through pretraining on atlas‐scale single‐cell data.
Yu Zhang, Baole Wen, Yifeng Jiao, Yuchen Liu, Xin Guo, Yushuai Wu, Jiyang Li, Limei Han, Yinghui Xu, Xin Gao, Yuan Qi, Yuan Cheng, Ying He, Weidong Tian   +13 more
wiley   +1 more source

Proinflammatory Cytokines Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells

, 2023
Ghiasi SM, Marchetti P, Piemonti L, Nielsen JH, Porse BT, Mandrup-Poulsen T, Rutter GA.   +6 more
europepmc   +1 more source

Nonsense-mediated RNA decay and its bipolar function in cancer. [PDF]

Mol Cancer, 2021
Nogueira G, Fernandes R, García-Moreno JF, Romão L.   +3 more
europepmc   +1 more source

An observational study of initial HIV RNA decay following initiation of combination antiretroviral treatment during pregnancy [PDF]

, 2020
Jasmini Alagaratnam, Helen Peters, Kate Francis, Natasha Kay, Yvonne Gilleece, Fionnuala Finnerty, Rosanna E Grimes, Sarah Parry, Mags Portman, Brenton Wait, Rimi Shah, Sherie Roedling, David Hawkins, Sarah Chitty, Liat Sarner, Rebecca Marcus, Anna Hartley, Achyuta Nori, Melanie Rosenvinge, Graham P. Taylor   +19 more
openalex   +1 more source

A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness

Advanced Science, EarlyView.
This study identifies a sub‐circuit within the circadian pacemaker suprachiasmatic nucleus (SCN) that promotes arousal. This sub‐circuit is labeled by the clock output molecule mWAKE, which suppresses its excitability in a time‐dependent manner. mWAKE‐expressing cells in the SCN (SCNmWAKE cells) project to the subparaventricular zone (SPZ) to mediate ...
Qiang Liu, Sang Soo Lee, Jiali Xiong, Shahin Ahmadi, Benjamin J. Bell, Mehmet F. Keles, Mark N. Wu   +6 more
wiley   +1 more source

MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer. [PDF]

Cancer Discov
Meena JK, Wang JH, Neill NJ, Keough D, Putluri N, Katsonis P, Koire AM, Lee H, Bowling EA, Tyagi S, Orellana M, Dominguez-Vidaña R, Li H, Eagle K, Danan C, Chung HC, Yang AD, Wu W, Kurley SJ, Ho BM, Zoeller JR, Olson CM, Meerbrey KL, Lichtarge O, Sreekumar A, Dacso CC, Guddat LW, Rejman D, Hocková D, Janeba Z, Simon LM, Lin CY, Pillon MC, Westbrook TF.   +33 more
europepmc   +1 more source

The nonstop decay and the RNA silencing systems operate cooperatively in plants [PDF]

, 2018
István Szádeczky-Kardoss, Tibor Csorba, Andor Auber, Anita Schamberger, Tünde Nyikó, János Taller, Tamás I. Orbán, József Burgyán, Dániel Silhavy   +8 more
openalex   +1 more source