Results 221 to 230 of about 1,912,865 (328)

The m⁶A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay. [PDF]

Proc Natl Acad Sci U S A, 2022
Macveigh-Fierro D, Cicerchia A, Cadorette A, Sharma V, Muller M.   +4 more
europepmc   +1 more source

Exosome-mediated decay of unstable long extended precursors of human telomerase RNA is dependent on 5′-cap trimethylation

Aniruddha Samajdar, Roberta Amato, Jai Il Youn, Ethan Cordes, Albert Tai, Grazia D. Raffa, Luis F Z Batista   +6 more
openalex   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells. [PDF]

Genes Dev, 2022
Burgess HM, Vink EI, Mohr I.
europepmc   +1 more source

Decay of RNA and Infectious SARS-CoV-2 and Murine Hepatitis Virus in Wastewater

, 2023
Kevin Purves, Liam J. Reynolds, Laura Sala‐Comorera, Niamh A. Martin, Darren Dahly, Wim Meijer, Nicola F. Fletcher   +6 more
openalex   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Cell type- and factor-specific nonsense-mediated RNA decay. [PDF]

Nucleic Acids Res
Tan K, Sebat J, Wilkinson MF.
europepmc   +1 more source

Nonmodular oscillator and switch based on RNA decay drive regeneration of multimodal gene expression. [PDF]

Nucleic Acids Res, 2022
Nordick B, Yu PY, Liao G, Hong T.
europepmc   +1 more source

Növényi RNS degradációs rendszerek: a nonsense-mediated decay rendszer molekuláris biológiája = RNA degradation systems in plants: the molecular biology of nonsense-mediated decay system [PDF]

, 2010
Dániel Silhavy, Anna Hangyáné Benkovics, Zoltán Kerényi, Zsuzsanna Mérai, Tünde Nyikó   +4 more
openalex  

HIDF: Integrating Tree‐Structured scRNA‐seq Heterogeneity for Hierarchical Deconvolution of Spatial Transcriptomics

Advanced Science, EarlyView.
The prevailing neglect of cellular hierarchies in current spatial transcriptomics deconvolution often obscures cellular heterogeneity and impedes the identification of fine‐grained subtypes. To address this issue, HIDF employs a cluster‐tree and dual regularization to systematically model cellular hierarchical structures.
Zhiyi Zou, Yuting Bai, Bo Wang, Wanwan Shi, Xiao Liang, Jiawei Luo   +5 more
wiley   +1 more source