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The Decay of Bacterial Messenger RNA
1996Publisher Summary The many demonstrations that the Escherichia coli (E. coli ) rne gene product (RNase E) is involved in messenger RNA (mRNA) decay have given real impetus to the study of this unusual protein's properties and role. The recent attention given to the polyadenylylation of bacterial mRNAs and the discovery that polyadenylylation ...
George J. Murakawa, Donald P. Nierlich
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Nature Neuroscience, 2007
Lasting synaptic plasticity requires precise local regulation of protein expression. A recent paper reports that the postsynaptic activity–induced arc mRNA is a target for rapid degradation by the 'nonsense-mediated decay' pathway.
Carol L. Peebles, Steven Finkbeiner
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Lasting synaptic plasticity requires precise local regulation of protein expression. A recent paper reports that the postsynaptic activity–induced arc mRNA is a target for rapid degradation by the 'nonsense-mediated decay' pathway.
Carol L. Peebles, Steven Finkbeiner
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Decay of RNA in RNA processing mutants of Escherichia coli
Molecular and General Genetics MGG, 1980Stability of RNA was tested in strains of Escherichia coli carrying single, double, or triple mutations in the RNA processing enzymes RNase III, RNase E and RNase P. Tests were carried out for total pulse labeled RNA, beta-galactosidase mRNA and for the decay of preexisting RNA during carbon starvation.
David Apirion, Darren R. Gitelman
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Chapter 4 Poly(A)‐Assisted RNA Decay and Modulators of RNA Stability
2009In Escherichia coli, RNA degradation is orchestrated by the degradosome with the assistance of complementary pathways and regulatory cofactors described in this chapter. They control the stability of each transcript and regulate the expression of many genes involved in environmental adaptation.
Eliane Hajnsdorf, Philippe Régnier
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Biphasic decay of guide RNAs in Trypanosoma brucei [PDF]
Molecular and Biochemical Parasitology, 2006 Guide RNAs (gRNAs) are short mitochondrially encoded RNAs that contain the information for editing of messenger RNAs in Trypanosoma brucei. Although a great deal of work has focused on the utilization of gRNAs in editing, little is known about the turnover of gRNAs. In this report, we utilized in organello pulse chase and in vitro RNA decay experiments
Laurie K. Read +3 more
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Out or decay: fate determination of nuclear RNAs
Essays in Biochemistry, 2020Abstract In eukaryotes, RNAs newly synthesized by RNA polymerase II (RNAPII) undergo several processing steps prior to transport to the cytoplasm. It has long been known that RNAs with defects in processing or export are removed in the nucleus.
Jianshu Wang, Hong Cheng
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Regulatory RNAs and target mRNA decay in prokaryotes
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013Recent advances in prokaryote genetics have highlighted the important and complex roles of small regulatory RNAs (sRNAs). Although blocking mRNA translation is often the main function of sRNAs, these molecules can also induce the degradation of target mRNAs using a mechanism that drastically differs from eukaryotic RNA interference (RNAi). Whereas RNAi
Lalaouna, David +3 more
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Nonsense mediated RNA decay and evolutionary capacitance
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016Nonsense mediated RNA decay (NMD) is well-known as an RNA quality control mechanism that sequesters a substantial portion of RNA from expression by targeting it for degradation. However, a number of recent studies across a range of organisms indicate a broader role for NMD in gene regulation and transcriptome homeostasis.
Vivek Kumar Raxwal, Karel Riha
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Chapter 10 RNA Polyadenylation and Decay in Mitochondria and Chloroplasts
2009Mitochondria and chloroplasts were originally acquired by eukaryotic cells through endosymbiotic events and retain their own gene expression machinery. One hallmark of gene regulation in these two organelles is the predominance of posttranscriptional control, which is exerted both at the gene-specific and global levels.
David B. Stern, Gadi Schuster
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Decay of transfer and total RNA in maturing reticulocytes
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971Abstract A gradual decrease in ribosomes and tRNA occurs during maturation of reticulocytes. The rate of decrease of ribosomes is higher than that of tRNA, so that there is a continuous increase in the proportion of tRNA to total RNA. No significant changes in the accepting activity of tRNA to a mixture of 16 amino acids could be observed during the ...
Tova Zehavi-Willner, David Danon
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