Results 121 to 130 of about 1,056,288 (288)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Assessment of the efficiency of virus extraction from food matrices and the frequency of occurrence of contaminated products in the retail network

Пищевые системы
Express detection of viruses, in particular, norovirus (NoV) and hepatitis A virus (HAV), is becoming an extremely important task for food safety control.
Yu. K. Yushina, A. A. Semenova, O. A. Kuznecova, D. M. Satabaeva, E. V. Zaiko, B. Velebit   +5 more
doaj   +1 more source

Investigation into the relationship between ethylene and sulfur assimilation in Arabidopsis thaliana and onion (Allium cepa L.) : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science (with Honours) in Biochemistry at Massey University [PDF]

, 2006
The phytohormone ethylene (C2H4) mediates the adaptive responses of plants to various nutrient deficiencies including iron (Fe)-deficiency, phosphorus (P)-deficiency and potassium (K)-deficiency.
Sanggang, Fiona Ann
core  

Impact of RNA extraction from limited samples on microarray results [PDF]

, 2003
Hanna Ojaniemi, Birgitta Evengård, Daisy R. Lee, Elizabeth R. Unger, Suzanne D. Vernon   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Nuclear RNA Fractions Obtained by Sequential Extraction of Rat Liver Nuclei with Salt Solutions and their Relationship to Polysome‐Associated RNA [PDF]

, 1969
J. Drews
openalex   +1 more source

Optimization of CTAB-based RNA Extraction Method for Aspergillus flavus [PDF]

, 2020
Virali Antala, Hemangini Chaudhari, Nidhi Radadiya, Hiral Desai, B. A. Golakiya, H. P. Gajera   +5 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Advances in Microfluidics and Lab-on-a-Chip Technologies

, 2017
Advances in molecular biology are enabling rapid and efficient analyses for effective intervention in domains such as biology research, infectious disease management, food safety, and biodefense.
Abate, Adley, Aebersold, Ahlford, Almassian, Almoguera, Asiello, Athamanolap, Baker, Becker, Blazej, Brehm-Stecher, Burger, Business-Wire, Byrnes, Cai, Cao, Chang, Chao, Chatterjee, Chin, Chin, Coupland, Craw, Crews, Crews, Czilwik, Derveaux, DeVoe, Dharmasiri, Dodsworth, Domon, Duffy, Erlich, Farrar, Fredrickson, Fu, Gagnon, Gao, Gonzalez de Castro, Grover, Hadd, Han, Hanyoup, Hardouin, Hauck, Hayden, He, He, He, Hindson, Ho, Hsieh, Huang, Hughes, Jacobs, Jansson, Jarvius, Jayamohan, Jayamohan, Jenkins, Jha, Ji, Jin, Jin, Kalra, Karimi, Karns, Khandurina, Kim, Kim, Kim, Kim, Kim, Klein, Klostranec, Konry, Kuroda, Kwasny, Kwasny, Kühnemund, Küster, Lagally, Lapierre, Lazar, Lazar, Lee, Lee, Lee, Li, Liu, Lochovsky, Macosko, Mahmoudian, Mani, Manz, Mao, Mariella, Melin, Mery, Metzker, Mezger, Mitchell, Mitchell, Neuzil, Ng, Northen, Oblath, Oxford Nanopore, Paegel, Paegel, Paliwal, Park, Pekin, Pennisi, Perez-Toralla, Pješčić, Pješčić, Pješčić, Prakash, Priye, Priye, Quick, Ro, Romanov, Safavieh, Sainiemi, Samuel, Sanvicens, Sato, Sayad, Schoenitz, Schuler, Shamsi, Shih, Song, Srbek, Stumpf, Sun, Sundberg, Tanaka, Teh, Tehranirokh, Thompson, Thuy, Tian, Tröger, Unger, Vergauwe, Volpatti, Weisenberger, Wheeler, Whitesides, Woolley, Xie, Xu, Xue, Yetisen, Yin, Zhang, Zhang, Zhu   +161 more
core   +1 more source