Chemistry – An Asian Journal, EarlyView.We report a versatile disulfide‐containing linkage to solid support that enables on‐column synthesis of DNA and RNA containing a 3′‐amino or 3′‐phosphate group. This orthogonal solid‐support linker enables a protecting group strategy for the synthesis of oligonucleotides containing 3′‐amino‐2′,3′‐dideoxyribosides directly from commercially available ...
Jagandeep S. Saraya +4 more
wiley +1 more source
Inhibiting NHEJ in HNSCC cell lines by the ligase IV inhibitor SCR130 has limited radiosensitizing effects. [PDF]
Sci RepHildebrand LS +6 more
europepmc +1 more source
BioEssays, EarlyView.Recent findings indicate that mitochondria‐associated membranes (MAMs), where the endoplasmic reticulum directly contacts the mitochondria, are a novel microdomain essential for cellular homeostasis, including proteostasis. We summarize the disruption of protein homeostasis and MAM alteration in neurodegenerative diseases, then discuss challenges and ...
Seiji Watanabe, Koji Yamanaka
wiley +1 more source
Nucleic acid joining enzymes: biological functions and synthetic applications beyond DNA. [PDF]
Biochem JBlackstock C +3 more
europepmc +1 more source
Dynamic protein interactions probed by NMR spectroscopy
Bulletin of the Korean Chemical Society, EarlyView.Abstract Dynamic protein–protein interactions are essential for diverse cellular processes but often evade structural characterization due to their transient, heterogeneous, and disordered nature. This review focuses on how nuclear magnetic resonance (NMR) spectroscopy can provide detailed, residue‐level insights into these complex interactions.
Jaeseok Lee, Jung Ho Lee
wiley +1 more source
An integrated proteo-transcriptomics approach reveals novel drug targets against multidrug resistant <i>Escherichia coli</i>. [PDF]
Front MicrobiolAswal M, Singh N, Singhal N, Kumar M.
europepmc +1 more source
Hijacking the MDM2 E3 Ligase with novel BRD4‐Targeting PROTACs in Pancreatic Cancer Cells
ChemBioChem, Accepted Article.The phenotypic effect induced by a Proteolysis‐Targeting Chimera (PROTAC) can depend on several factors, including the E3 ligase recruited. For the discovery of a first‐in‐class PROTAC for a target of interest, the E3 ligases commonly hijacked remain the Von Hippel‐Lindau (VHL) and Cereblon (CRBN) since potent and accessible ligands are readily ...
Mihaela Ficu +4 more
wiley +1 more source
ATP-Dependent Chromatin Remodeler CSB Couples DNA Repair Pathways to Transcription with Implications for Cockayne Syndrome and Cancer Therapy. [PDF]
CellsBilkis R, Lake RJ, Fan HY.
europepmc +1 more source
Chromenone derivatives as CRM1 Inhibitors for Targeting Glioblastoma
ChemBioChem, Accepted Article.Glioblastoma (GBM) is one of the most aggressive and deadly cancers. Due to the complexity and redundancy within signaling networks in GBM, targeted inhibitors of specific pathways have shown only limited success. The nuclear export receptor Chromosome Region Maintenance 1 (CRM1) has recently emerged as a promising therapeutic target, as its inhibition
Wolfgang Link +10 more
wiley +1 more source
Biochemical basis of endogenous bioluminescent springtail Lobella sauteri (Collembola). [PDF]
Biol OpenBessho-Uehara M +4 more
europepmc +1 more source