Results 161 to 170 of about 115,962 (247)

Effects of Biofilm Formation on Gastrointestinal Tolerance, Mucoadhesion and Transcriptomic Responses of Probiotics. [PDF]

Food Sci Nutr
Gao W, Jing H, Qiu B, Zhang S, Zhang J, Xu L, Ba F, Xie S, Liu XM, Li L, Yao M.   +10 more
europepmc   +1 more source

Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley   +1 more source

Identification and validation of reference genes with stable expression under elicitor treatments of the medicinal plant Arnica montana L. [PDF]

BMC Plant Biol
Sozoniuk M, Petrova M, Mishev K, Miladinova-Georgieva K, Geneva M.   +4 more
europepmc   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

LMNA R482L mutation causes impairments in C2C12 myoblasts subpopulations, alterations in metabolic reprogramming during differentiation, and oxidative stress. [PDF]

Sci Rep
Ivanova OA, Predeus AV, Sorokina MY, Ignatieva EV, Bobkov DE, Sukhareva KS, Kostareva AA, Dmitrieva RI.   +7 more
europepmc   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Insights into the Antimicrobial Mechanisms of a Scorpion Defensin on <i>Staphylococcus aureus</i> Using Transcriptomic and Proteomic Analyses. [PDF]

Molecules
Yang X, Zhang H, Lu S, Guo Y, Li Y, Qin C, Zuo Z, Wu Y, Cao Z.   +8 more
europepmc   +1 more source

The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated‐B Cells

Exploration, EarlyView.
Bcas2 recruits DHX15 and SRSF7 to form a protein complex for the splicing of CSR‐related mRNA at the 5' ss and 3' ss, generating two mature mRNA isoforms, which are ultimately translated into CSR‐related proteins. These CSR‐related proteins bind to DNA associated with antibodies, affecting the DSB repair of the relevant DNA after AID induction, thereby
Yu Chen, Siyuan Sun, Chenxu Lu, Yixuan Li, Bing Fang, Xiangfeng Tang, Xuepeng Li, Weiru Yu, Yumei Lei, Longjie Sun, Ming Zhang, Jiazeng Sun, Ping Liu, Yongting Luo, Xingwang Zhao, Jing Zhan, Libing Liu, Rong Liu, Jiaqiang Huang, Ziwei Yi, Yifei Yu, Weihan Xiao, Zheng Ding, Lei Li, Dan Su, Fazheng Ren, Changchang Cao, Ran Wang, Wenbiao Shi, Juan Chen   +29 more
wiley   +1 more source

The Function of TRIM25 in Antiviral Defense and Viral Immune Evasion. [PDF]

Viruses
Liu Q, Peng S, Wei J, Xie Z.
europepmc   +1 more source

Application of Ferulic Acid to Alleviate Chilling Injury of Banana Fruit by Regulating Redox, Phenylpropanoid, and Energy Metabolism

Food Frontiers, EarlyView.
This study investigated the effect of ferulic acid (FA) on the cold tolerance of banana fruit under 6°C‐storage for 7 days. In comparison with control, 3 mM FA treatment significantly alleviated chilling symptoms of banana fruit by enhancing phenylpropanoid metabolism and maintaining redox and energy homeostasis. ABSTRACT Banana fruit is susceptible to
Yu Hou, Min Gou, Zhengke Zhang, Lanhuan Meng, Lisha Zhu, Xiangbin Xu, Taotao Li, Yueming Jiang, Jianbo Xiao, Jiali Yang   +9 more
wiley   +1 more source