Results 181 to 190 of about 115,962 (247)

Phage‐mediated horizontal transfer of Salmonella enterica virulence genes with regulatory feedback from the host

iMeta, EarlyView.
In this study, we found evidence of phage‐mediated horizontal transfer of virulence genes in Salmonella enterica in global habitats from a molecular evolutionary perspective. Notably, csrA, a global regulator in Salmonella enterica, curbed horizontal gene transfer by inhibiting the cyclization and release of prophage.
Tianjing She, Demeng Tan, Jose Luis Balcazar, Ville‐Petri Friman, Danrui Wang, Dong Zhu, Mao Ye, Mingming Sun, Shujian Yuan, Feng Hu   +9 more
wiley   +1 more source

RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells. [PDF]

Nucleic Acids Res
Zhang K, Nie Q, Li M, Chen X, Zhong L, Dai T, Guo X, Zhao H, Lau TC, Wang H, Chen SB, Kwok CK.   +11 more
europepmc   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Substrate recognition by a peptide-aminoacyl-tRNA ligase. [PDF]

Proc Natl Acad Sci U S A
Ramos-Figueroa J, Liang H, van der Donk WA.   +2 more
europepmc   +1 more source

Impacts of Inorganic Arsenic Exposure on Genetic Stability of Human Mesenchymal Stromal Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human mesenchymal stem/stromal cells (hMSCs) can differentiate into mesoderm‐type cells, making them suitable candidates for tissue repair therapies. However, their relatively low frequency in adult tissue necessitates ex vivo expansion prior to regenerative medicine applications, and therefore, long‐term hMSC genetic stability during ...
Marc A. Beal, Melanie Coughlan, Andrée Nunnikhoven, Reena Corbane, Cathy Cummings‐Lorbetskie, Andrea Rowan‐Carroll, Tanvi Sharma, Andrew Williams, Jessie R. Lavoie, Andrew Stalker, Asish Mohapatra, Matthew J. Meier   +11 more
wiley   +1 more source

Analysis of Processing, Post-Maturation, and By-Products of shRNA in Gene and Cell Therapy Applications. [PDF]

Methods Protoc
Hong Z, Tesic N, Bofill-De Ros X.
europepmc   +1 more source

The Function of TER94 of Spodoptera frugiperda 9 Cells When Infected With Invertebrate Iridescent Virus‐6

Journal of Basic Microbiology, EarlyView.
ABSTRACT The 118 L protein in the envelope of the Invertebrate iridescent virus 6 (IIV6) is responsible for binding to receptors on the surface of permissive cells. We previously elucidated its function by silencing its gene and neutralizing the protein with antibodies.
Kubra Zengin, Cihan Inan, Remziye Nalcacioglu, Zihni Demirbag   +3 more
wiley   +1 more source

17-beta estradiol prevents cardiac myocyte hypertrophy by regulating mitochondrial E3 ubiquitin ligase 1. [PDF]

Cell Death Dis
Calle X, Garrido-Moreno V, Becerra B, Troncoso MF, Silva-Agüero JF, Guajardo-Correa E, Venegas-Zamora L, Lopez-Gallardo E, Muñoz-Córdova F, Fredericksen F, Aedo-Cares S, Peñaloza-Otárola A, Ortega A, Raya A, Maracaja-Coutinho V, Chiong M, Parra V, Lavandero S.   +17 more
europepmc   +1 more source

Self‐Assembly of Noncanonical Peptides: A New Frontier in Cancer Therapeutics and Beyond

Macromolecular Bioscience, EarlyView.
Representative examples of noncanonical peptide assemblies in anticancer therapeutics, biomaterials, regenerative medicine, molecular imaging, and catalysis are discussed, highlighting enzyme‐instructed self‐assembly as a valuable approach for constructing biomimetic and bioinspired materials that bridge the interface between biological systems and ...
Lin Bai, Meihui Yi, Bing Xu
wiley   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source