Results 191 to 200 of about 115,962 (247)

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

A Commentary on Mitochondrial Dysfunction and Compromised DNA Repair in Neurodegeneration: The Emerging Role of FUS in ALS. [PDF]

Neurosci Insights
Kodavati M, Hegde ML.
europepmc   +1 more source

Neuroprotective Potential of the Flavonoids Quercetin and Epicatechin in a C. elegans Tauopathy Model

Molecular Nutrition &Food Research, EarlyView.
Epicatechin and quercetin enhanced healthspan in the C. elegans BR5270 tauopathy model, associated with the upregulation of autophagy‐related and α‐tubulin synthesis genes, and the downregulation of genes involved in the unfolded protein response. ABSTRACT The prevalence of cognitive disorders such as Alzheimer's disease (AD) is increasing due to the ...
Lidia Garzón‐García, Begoña Ayuda‐Durán, Susana González‐Manzano, Celestino Santos‐Buelga, Ana M. González‐Paramás   +4 more
wiley   +1 more source

PPTC7 acts as an essential co-factor of the SCF^FBXL4 ubiquitin ligase complex to restrict BNIP3/3L-dependent mitophagy. [PDF]

Cell Death Dis
Xu X, Chen Y, Fei S, Jiang X, Zhou X, Xue Y, Li Y, Zhao SM, Huang Y, Wang C.   +9 more
europepmc   +1 more source

Cystathionine gamma‐lyase‐mediated hypoxia inducible factor 1‐alpha expression drives clear cell ovarian cancer progression

The Journal of Pathology, EarlyView.
Abstract Clear cell ovarian cancer (CCOC) is the second most common ovarian cancer subtype, accounting for 5%–11% of ovarian cancers in North America. Late‐stage CCOC is associated with a worse prognosis compared to other ovarian cancer histotypes, a challenge that has seen limited progress in recent decades.
Amal M EL‐Naggar, Yuqin Li, Busra Turgu, Yuchen Ding, Longyijie Wei, Shary Yuting Chen, Genny Trigo‐Gonzalez, Forouh Kalantari, Rodrigo Vallejos, Branden Lynch, Janine Senz, Amy Lum, J Maxwell Douglas, Clara Salamanca, Shelby Thornton, Yimei Qin, Kiran Parmar, Sandra E Spencer, Samuel Leung, Michelle MM Woo, Paul J Yong, Hai‐Feng Zhang, Christopher S Hughes, Gian Luca Negri, Yemin Wang, Gregg B Morin, Poul H Sorensen, David G Huntsman   +27 more
wiley   +1 more source

Preparation of topoisomers of short circular dsDNA with defined linking number by accurate topological control. [PDF]

Nucleic Acids Res
Liu M, Wang Z, An R, Li A, Liang X.
europepmc   +1 more source

Identification of Prognostic Biomarkers in Gene Expression Profile of Neuroblastoma Via Machine Learning

Pediatric Discovery, EarlyView.
This study identified 11 core prognostic biomarkers for neuroblastoma through optimized PPI networks and machine learning, revealing their correlations with chemotherapy and the tumor microenvironment, providing new insights for precision treatment and target development.
Shuxin Tang, Jinhua Fan, Yupeng Cun
wiley   +1 more source

Label-free proteomic analysis of Duchenne and Becker muscular dystrophy showed decreased sarcomere proteins and increased ubiquitination-related proteins. [PDF]

Sci Rep
da Silva JCT, Nogueira MRA, da Silva YM, Nogueira FCS, Canedo NHS, Carneiro K, de Abreu Pereira D.   +6 more
europepmc   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Molecular Identification and Bioinformatics Analysis of <i>Anaplasma marginale</i> Moonlighting Proteins as Possible Antigenic Targets. [PDF]

Pathogens
Quiroz-Castañeda RE, Aguilar-Díaz H, Coronado-Villanueva E, Catalán-Ochoa DI, Amaro-Estrada I.   +4 more
europepmc   +1 more source