Results 201 to 210 of about 82,511 (219)

Inhibition of the First Stage of RNA Ligase Reaction by ATP Analogues

Nucleosides and Nucleotides, 1991
Abstract It was shown that most ATP analogues which am modified with respect to polyphosphate part of the molecule are competitive inhibitors of the first stage of the RNA ligase reaction. All investigated compounds, with the exception of AMP and ADP, from a covalent AMP-RNA ligase complex.
Benediktas Juodka, D. Labeiltyte
semanticscholar   +3 more sources

Structure and mechanism of a eukaryal nick-sealing RNA ligase K170M+ATP

, 2015
Mihaela-Carmen Unciuleac, Yehuda Goldgur, Stewart Shuman   +2 more
openalex   +2 more sources

Archaeal ATP-dependent RNA ligase - form 2

, 2015
K.S. Murakami
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[Study of ATP-independent stages of reaction catalyzed by phage T4 RNA-ligase].

Molekuliarnaia biologiia, 1987
The isotope exchange between [5'-32P]pAP and A(5')ppAp catalyzed by enzyme was shown not to take place in the absence of the acceptor; i. e. the necessity of the acceptor presence during the second step of the process was demonstrated. The isotope exchange reaction between [5'32P]pAp and (pA)5p was studied.
Zagrebel'nyĭ Sn, Zernov IuP
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[Inhibitory effect of ATP gamma-anilide in reactions catalyzed by amino acid:tRNA ligases and DNA-dependent RNA polymerase].

Doklady Akademii nauk SSSR, 1974
Babkina Gt, Knorre Vl, Knorre Dg, Lavrik Oi   +3 more
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[Kinetic characteristics of the ATP-pyrophosphate isotope exchange catalyzed by RNA ligase from T4 bacteriophage].

Molekuliarnaia biologiia, 1984
The dependence of initial rate v0 of ATP--PPi exchange reaction catalyzed by RNA-ligase of bacteriophage T4 on the concentration of ATP(s), pyrophosphate (z) and Mgcl2 has been determined. The dependence of v0 on s and z described by the equation v0 = k-1k2E0/(k-1 + K2) (1 + K1/s + k2/z) has been obtained for the reaction of E + S in equilibrium ES in ...
Zagrebel'nyĭ Sn, Zernov IuP, Knorre Dg
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[Study of the substrate specificity of T4 RNA ligase: interaction of the enzyme with ATP analogs modified through the ribose residue and with affinity sorbents].

Biokhimiia (Moscow, Russia), 1995
To elucidate the role of the ribose moiety in substrate binding, various ATP derivatives modified in ribose moiety were studied as probes for the T4 RNA ligase first stage reaction. The kinetic parameters for competitive inhibition were determined. Inhibition experiments using substrate analogs demonstrated that the major binding determinants of ATP ...
B A Iuodka, D Ia Labeĭkite, V L Sabaliauskene   +2 more
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Characterization of tRNA splicing enzymes RNA ligase and tRNA 2′-phosphotransferase from the pathogenic fungi Mucorales

RNA: A publication of the RNA Society
Fungal Trl1 is an essential trifunctional tRNA splicing enzyme that heals and seals tRNA exons with 2′,3′-cyclic-PO4 and 5′-OH ends. Trl1 is composed of C-terminal cyclic phosphodiesterase and central polynucleotide kinase end-healing domains that ...
Shreya Ghosh, S. Dantuluri, A. Jacewicz, Ana M. Sanchez, Leonora Abdullahu, M. Damha, B. Schwer, Stewart Shuman   +7 more
semanticscholar   +1 more source

Probing and Enhancing DNA Ligase Specificity via Se-Atom-Mutagenesis of ATP for Accurate Gene Synthesis and Detection.

Angewandte Chemie
Discriminating against base-pair mismatches by nucleic acid-related enzymes is essential for DNA replication, RNA replication, nucleic acid repair, transcription, and translation.
Dejin Xu, B. Hu, Xiaoling Ding, Tong Qin, Ting Li, Jiaxin Li, Danyan Luo, Lu Chen, Yunfan Xu, Jun Zhang, Han Kang, Yang Zhang, Zhen Huang   +12 more
semanticscholar   +1 more source

A human RNA ligase that operates via auto- and RNA-AMPylation

bioRxiv, 2022
Yizhi Yuan, Florian M. Stumpf, Lisa A. Schlor, Olivia P. Schmidt, Luisa B. Huber, Matthias Frese, M. Scheffner, Florian Stengel, K. Diederichs, A. Marx   +9 more
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