Results 21 to 30 of about 82,511 (219)

Chemoproteomic discovery of a human RNA ligase

Nature Communications, 2023
RNA ligases are present across all forms of life. While enzymatic RNA ligation between 5′-PO_4 and 3′-OH termini is prevalent in viruses, fungi, and plants, such RNA ligases are yet to be identified in vertebrates. Here, using a nucleotide-based chemical
Yizhi Yuan, Florian M. Stumpf, Lisa A. Schlor, Olivia P. Schmidt, Philip Saumer, Luisa B. Huber, Matthias Frese, Eva Höllmüller, M. Scheffner, Florian Stengel, K. Diederichs, A. Marx   +11 more
semanticscholar   +1 more source

Functional and structural insights revealed by molecular dynamics simulations of an essential RNA editing ligase in Trypanosoma brucei. [PDF]

PLoS Neglected Tropical Diseases, 2007
RNA editing ligase 1 (TbREL1) is required for the survival of both the insect and bloodstream forms of Trypanosoma brucei, the parasite responsible for the devastating tropical disease African sleeping sickness.
Rommie E Amaro, Robert V Swift, J Andrew McCammon   +2 more
doaj   +1 more source

Template-directed ligation of tethered mononucleotides by t4 DNA ligase for kinase ribozyme selection. [PDF]

PLoS ONE, 2010
BACKGROUND: In vitro selection of kinase ribozymes for small molecule metabolites, such as free nucleosides, will require partition systems that discriminate active from inactive RNA species.
David G Nickens, Nirmala Bardiya, James T Patterson, Donald H Burke   +3 more
doaj   +1 more source

Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity

eLife, 2023
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with a likely oligogenic etiology, but our understanding of the genetic complexities and pathogenic mechanisms leading to HLHS is limited.
Katja Birker, Shuchao Ge, Natalie J Kirkland, Jeanne L Theis, James Marchant, Zachary C Fogarty, Maria A Missinato, Sreehari Kalvakuri, Paul Grossfeld, Adam J Engler, Karen Ocorr, Timothy J Nelson, Alexandre R Colas, Timothy M Olson, Georg Vogler, Rolf Bodmer   +15 more
doaj   +1 more source

Direct adenylation from 5′-OH-terminated oligonucleotides by a fusion enzyme containing Pfu RNA ligase and T4 polynucleotide kinase

Nucleic Acids Research, 2022
5′-Adenylated oligonucleotides (AppOligos) are widely used for single-stranded DNA/RNA ligation in next-generation sequencing (NGS) applications such as microRNA (miRNA) profiling.
Zhengquan Yang, Chengliang Zhang, Guojun Lian, Shijie Dong, Menghui Song, Hengrong Shao, Jingmei Wang, Tao Zhong, Zhenni Luo, Shengnan Jin, Chunming Ding   +10 more
semanticscholar   +1 more source

The RNA editing patterns are different in blood of euthymic and depressed bipolar patients

European Psychiatry, 2023
Introduction Bipolar disorder (BD) is a severe mental disorder associated with functional impairment, high disability and premature mortality. Modifications of editing in mRNA of serotonin receptor subtype 2C (5-HTR2c) was reported by us in depressed ...
M. Hayashi, N. Salvetat, C. Cayzac, F. J. Checa-Robles, C. Lozano, J.-D. Abraham, B. Dubuc, S. Mereuze, J. V. Nani, F. Molina, E. Brietske, D. Weissmann   +11 more
doaj   +1 more source

Altered m6A RNA methylation governs denervation-induced muscle atrophy by regulating ubiquitin proteasome pathway

Journal of Translational Medicine, 2023
Background Denervation-induced muscle atrophy is complex disease involving multiple biological processes with unknown mechanisms. N6-methyladenosine (m6A) participates in skeletal muscle physiology by regulating multiple levels of RNA metabolism, but its
Junjie Sun, Hai Zhou, Zehao Chen, Han Zhang, Yanzhe Cao, Xinlei Yao, Xin Chen, Boya Liu, Zihui Gao, Yuntian Shen, Lei Qi, Hualin Sun   +11 more
doaj   +1 more source

A meta-quantitative trait loci analysis identified consensus genomic regions and candidate genes associated with grain yield in rice

Frontiers in Plant Science, 2022
Improving grain yield potential in rice is an important step toward addressing global food security challenges. The meta-QTL analysis offers stable and robust QTLs irrespective of the genetic background of mapping populations and phenotype environment ...
Kelvin Dodzi Aloryi, Nnaemeka Emmanuel Okpala, Aduragbemi Amo, Semiu Folaniyi Bello, Selorm Akaba, Xiaohai Tian   +5 more
doaj   +1 more source

Growth arrest and DNA damage‐inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Skeletal muscle fat infiltration is a common feature during ageing, obesity and several myopathies associated with muscular dysfunction and sarcopenia.
Wenjing You, Shiqi Liu, Jianfei Ji, Defeng Ling, Yuang Tu, Yanbing Zhou, Wentao Chen, Teresa G. Valencak, Yizhen Wang, Tizhong Shan   +9 more
doaj   +1 more source

Antibody-validated proteins in inflamed islets of fulminant type 1 diabetes profiled by laser-capture microdissection followed by mass spectrometry. [PDF]

PLoS ONE, 2014
There are no reports of proteomic analyses of inflamed islets in type 1 diabetes.Proteins expressed in the islets of enterovirus-associated fulminant type 1 diabetes (FT1DM) with extensive insulitis were identified by laser-capture microdissection mass ...
Yoriko Nishida, Kaoru Aida, Makoto Kihara, Tetsuro Kobayashi   +3 more
doaj   +1 more source