Deregulation of m6A-RNA methylation impairs adaptive hypertrophic response and drives maladaptation via mTORC1-S6K1-hyperactivation and autophagy impairment. [PDF]
Annamalai K +17 more
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Identification of a novel m6A RNA methylation regulator-based signature for prognosis and immune landscape prediction in hepatocellular carcinoma. [PDF]
Wang H, Wang D, Jiang T, Wang H, Li L.
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m6A RNA methylation regulator-associated genes drive metastasis and immune cell infiltration in skin cutaneous melanoma. [PDF]
Geng Y, Zhao S, Geng T, Xu XL, Zhang X.
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The multifaceted role of m5C RNA methylation in digestive system tumorigenesis. [PDF]
Hu X, Liu Y, Zhang S, Liu K, Gu X.
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Betaine alleviates hepatic lipid metabolism disorder in finishing pigs fed a low-energy diet through regulating m<sup>6</sup>A RNA methylation. [PDF]
Liang C +8 more
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METTL3/IGF2BP2-Mediated m6A RNA Methylation Drives Alveolar Macrophage-Dependent Neutrophil Recruitment in Cigarette Smoke-Induced COPD. [PDF]
Lin A, Wang J, Wang L, Zhang Y.
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Integrated multi-omics analysis identifies key biomarkers associated with post-translational modifications and RNA methylation in clear cell renal cell carcinoma. [PDF]
Pang T, He Y, Liao J, Wei X.
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AbstractMethylation of RNA occurs at a variety of atoms, nucleotides, sequences and tertiary structures. Strongly related to other posttranscriptional modifications, methylation of different RNA species includes tRNA, rRNA, mRNA, tmRNA, snRNA, snoRNA, miRNA, and viral RNA.
Yuri, Motorin, Mark, Helm
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RNA methylations in human cancers
Seminars in Cancer Biology, 2021RNA methylations, as the prevalent post-transcriptional modifications, are critical in regulating various biological processes, such as RNA transcription, splicing, structure, stability, and translation. Its dysregulation is closely related to the occurrence of human malignancies.
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Double-stranded RNAs (dsRNAs) and their `diced' small RNA products can guide key developmental and defense mechanisms in eukaryotes. Some RNA-directed mechanisms act at a post-transcriptional level to degrade target messenger RNAs. However, dsRNA-derived species can also direct changes in the chromatin structure of DNA regions with which they share ...
Mathieu, Olivier, Bender, Judith
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