Results 251 to 260 of about 248,618 (295)

Methylation of RNA Purine-Bases by Methyl Radicals

Archives of Biochemistry and Biophysics, 1993
During the metabolism of 1,2-dimethylhydrazine (a colon carcinogen) in rats, methyl radicals (.CH3) are produced. To gain an insight into the nature of .CH3 interactions with biomolecules in vivo, we conducted in vitro studies using RNA as a model compound.
J O, Kang, K S, Gallagher, G, Cohen
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RNA-directed DNA methylation

Journal of Cell Science, 2004
Double-stranded RNAs (dsRNAs) and their `diced' small RNA products can guide key developmental and defense mechanisms in eukaryotes. Some RNA-directed mechanisms act at a post-transcriptional level to degrade target messenger RNAs. However, dsRNA-derived species can also direct changes in the chromatin structure of DNA regions with which they share ...
Mathieu, Olivier, Bender, Judith
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A study of transfer RNA methylation

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
Abstract The process of enzymatic methylation was studied with yeast tRNAVal1, using as a source of enzyme the protein fraction precipitated from the 105 000 × g supernatant of both rat liver and hepatoma by 50 % (NH4)2SO4 saturation. Under the conditions chosen, the extent of methylation with the hepatoma enzyme was about 1 mole of methyl ...
L P, Shershneva, T V, Venkstern, A A, Bayev   +2 more
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Biological roles of adenine methylation in RNA

Nature Reviews Genetics, 2022
N6-Methyladenosine (m6A) is one of the most abundant modifications of the epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in detection and mapping methods have improved our understanding of the effects of m6A on mRNA fate and ribosomal RNA function, and have uncovered novel functional roles in virtually every ...
Konstantinos Boulias, Eric Lieberman Greer   +1 more
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Nucleolus: A Center of RNA Methylation

Science, 1963
The ubiquitously distributed complex of enzymes, the RNA methylases, the apparent function of which is the alteration of the structure of transfer RNA at the macromolecular level by the introduction of methyl groups into the component bases, are concentrated in the nucleolus, an organelle previously implicated in RNA synthesis.
Birnstiel, Max L., Fleissner, Erwin, Borek, Ernest   +2 more
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RNA Methylation and Control of Eukaryotic RNA Biosynthesis

European Journal of Biochemistry, 1977
The role of RNA methylation in the control of ribosome production in mammalian cells has been reinvestigated through a study of the effects in vivo of cycloleucine, a specific and reversible inhibitor of nucleic acid methylations.No close coupling is observed between methylation and transcription.
Caboche, Michel, M., Bachellerie, J.P.
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RNA-directed DNA methylation

Plant Molecular Biology, 2000
RNA-DNA interactions can serve as a signal that triggers de novo DNA methylation in plants. As yet, this RNA-directed DNA methylation mechanism merely targets transgenes, but it appears likely that methylation of some endogenous sequences is also directed by RNA.
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Mitochondrial RNA methylation in cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Mitochondria have a complete and independent genetic system with necessary biological energy for cancer occurrence and persistence. Mitochondrial RNA (mt-RNA) methylation, as a frontier in epigenetics, has linked to cancer progression with growing evidences.
Luyi, Tan, Chenyu, Zhu, Xinyu, Zhang, Jiaqi, Fu, Tingting, Huang, Wenji, Zhang, Wenjuan, Zhang   +6 more
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Methylation of rat-liver RNA in vivo by methyl methanesulphonate

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1969
Abstract The time-course of methylation of rat-liver RNA in vivo was determined following intraperitoneal injection of a single dose (50–57 mg/kg body weight) of [14C]methyl methanesulphonate. The purified RNA was subjected to acid hydrolysis and the products were separated by ion-exchange chromatography.
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Methylation of Mouse Ribosomal RNA Genes

DNA, 1982
Ribosomal DNA (rDNA) methylation was studied in various strains of mice. We used restriction enzymes that are sensitive to methylation and a cloned probe containing the transcribed spacer and part of the 18S and 28S gene. Strains C3H/He3, C57/B6-3, and AKR/J were found to have less than 9% of the rDNA methylated.
J G, Reilly, C A, Thomas, M J, Lundell
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