Results 321 to 330 of about 753,590 (330)
Some of the next articles are maybe not open access.
Heterogeneity of chemical modifications on RNA
Biophysical Reviews, 2023The chemical modifications of RNAs broadly impact almost all cellular events and influence various diseases. The rapid advance of sequencing and other technologies opened the door to global methods for profiling all RNA modifications, namely the "epitranscriptome." The mapping of epitranscriptomes in different cells and tissues unveiled that RNA ...
W. S. Sho Goh, Yi Kuang
openaire +3 more sources
RNA modifications in hematological malignancies
International Journal of Hematology, 2023RNA modifications play an important role in various cancers including blood cancers by controlling gene expression programs critical for survival, proliferation and differentiation of cancer cells. While hundreds of RNA modifications have been identified, many have not been functionally characterized.
Zhen Jin +3 more
openaire +2 more sources
Messenger RNA Modifications in Plants
Trends in Plant Science, 2019Over 160 distinct RNA modifications are known and collectively termed the epitranscriptome. Some of these modifications have been discovered in mRNA, uncovering a new layer of gene regulation. Transcriptome-wide mapping of epitranscriptomic codes and the discovery of their writers, erasers, and readers that dynamically install, remove, and interpret ...
Chui E. Wong +3 more
openaire +3 more sources
The chemical diversity of RNA modifications
Biochemical Journal, 2019Abstract Nucleic acid modifications in DNA and RNA ubiquitously exist among all the three kingdoms of life. This trait significantly broadens the genome diversity and works as an important means of gene transcription regulation. Although mammalian systems have limited types of DNA modifications, over 150 different RNA modification types ...
R. Jordan Ontiveros +2 more
openaire +3 more sources
Dynamic RNA modifications in disease
Current Opinion in Genetics & Development, 2014While the presence of 6-methyladenosine (m6A) modifications in mRNA was noted several decades ago, the first enzyme reversing this modification was identified very recently. Today we know of two methyltransferases introducing m6A in mRNA--METTL3 and METTL14--and two demethylases that remove it have been identified-FTO (ALKBH9) and ALKBH5. The conserved
John Arne Dahl, Arne Klungland
openaire +3 more sources
Sequencing diverse RNA modifications
Nature Methods, 2021Nanopore sequencing enables quantitative profiling of pseudouridine and 2′-O-methylation modifications in native RNAs.
openaire +3 more sources
Catalysts for RNA and DNA modification
Current Opinion in Chemical Biology, 2015To study DNAs and RNAs it is often necessary to chemically modify them. Nature's strategy for nucleic acid modification is to use selective catalysts, and chemists have begun to emulate this conceptual approach. In this review we present a summary of catalytic approaches toward the construction of modified RNAs and DNAs and outline our opinions on ...
Gillingham, Dennis, Shahid, Ramla
openaire +4 more sources
Messenger RNA editing and modification
Current Opinion in Cell Biology, 1989openaire +3 more sources