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Gold Nanoparticles as Carriers for Functional RNA Nanostructures
Bioconjugate Chemistry, 2021Conjugates of gold nanoparticles and ribonucleic acid are particularly interesting for biological applications to serve as therapeutics or biosensors. In this paper we present, for the first time, a conjugate of gold nanoparticles and structural RNA (tectoRNA), which serves as a tool for gene expression regulation.
Anna Graczyk +2 more
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Self-assembled RNA nanostructures
Science, 2014RNA structures have been designed that self-assemble and are programmable and scalable [Also see Report by Geary et al. ]
Leontis, N, Westhof, Eric
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Nanostructured RNAs for RNA Interference
2014We synthesized three types of nanostructured RNAs that induce RNA interference (RNAi): branched RNAs, dumbbell-shaped RNA, and circular double-stranded RNAs. All three nanostructured RNAs were transformed into double-stranded RNA of approximately 20 base pairs when they were treated with nuclease enzymes such as Dicer.
Yuko, Nakashima +3 more
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Modeling ligand docking to RNA in the design of RNA-based nanostructures
Current Opinion in Biotechnology, 2020RNA has grown in biological importance as the discovery of its many functional roles in the cellular machinery has revealed the potential for targeting it to disrupt cancer pathways. RNA structure underlies its functionality and suitability as a nanoparticle building material.
Wojciech Kajetan, Kasprzak +2 more
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The architectonics of programmable RNA and DNA nanostructures
Current Opinion in Structural Biology, 2006The past several years have witnessed the emergence of a new world of nucleic-acid-based architectures with highly predictable and programmable self-assembly properties. For almost two decades, DNA has been the primary material for nucleic acid nanoconstruction.
Luc, Jaeger, Arkadiusz, Chworos
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RNA nanostructures and scaffolds for biotechnology applications
Current Opinion in Biotechnology, 2019RNA plays important roles in the regulation of gene expressions and other cellular functions. It functions as both as an informational carrier and a nanomachine due to its complementary base-pairing ability and complexed three-dimensional structure. Several nanostructures have been designed and constructed by exploiting these natural RNA properties. In
Hirohisa, Ohno +2 more
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A Nanostructure Made of a Bacterial Noncoding RNA
Journal of the American Chemical Society, 2009Natural RNAs, unlike many proteins, have never been reported to form extended nanostructures, despite their wide variety of cellular functions. This is all the more striking, as synthetic DNA and RNA forming large nanostructures have long been successfully designed. Here, we show that DsrA, a 87-nt noncoding RNA of Escherichia coli, self-assembles into
Cayrol, Bastien +5 more
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Computer-Assisted Design and Characterization of RNA Nanostructures
2023Molecular dynamics (MD) simulations can aid in the design and characterization of RNA nanomaterials, providing details about structural and dynamical properties as a function of sequence and environment. Here, we describe how to perform explicit and implicit solvent all-atom MD simulations for RNA nanoring systems.
Christina J, Bayard +1 more
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Protocols for the In Silico Design of RNA Nanostructures
2008Recent developments in the field of nanobiology have significantly expanded the possibilities for new modalities in the treatment of many diseases, including cancer. Ribonucleic acid (RNA) represents a relatively new molecular material for the development of these biologically oriented nanodevices. In addition, RNA nanobiology presents a relatively new
Bruce A, Shapiro +3 more
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Discriminating Immunorecognition Pathways Activated by RNA Nanostructures
2023Nucleic acid nanoparticles (NANPs) composed of therapeutic DNA, RNA, or a hybrid of both are increasingly investigated for their targeted and tunable immunomodulatory properties. By taking advantage of the NANPs' unique and relatively straightforward self-assembling behavior, nucleic acid sequences can be designed from the bottom-up and specifically ...
Leyla, Danai +2 more
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