Results 251 to 260 of about 811,464 (309)

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Cell-type-specific RNA polymerase II activity maps in intact tissues provide a gateway to mammalian gene regulatory mechanisms in vivo. [PDF]

Dev Cell
Chovatiya G, Huang SY, Wang AB, Versluis P, Bai CK, DeBerardine M, Liao YC, Ray J, Ozer A, Lis JT, Tumbar T.   +10 more
europepmc   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Phosphorylation modulates secondary structure of intrinsically disorder regions in RNA polymerase II. [PDF]

J Biol Chem
Chen W, Laremore TN, Yennawar NH, Showalter SA.   +3 more
europepmc   +1 more source

Mouse promoters are characterised by low occupancy and high turnover of RNA polymerase II. [PDF]

Mol Syst Biol
Chatsirisupachai K, Moene CJI, Kleinendorst R, Kreibich E, Molina N, Krebs A.   +5 more
europepmc   +1 more source

Transcriptional coordination between intergenic RNA polymerase II-bound regions and nearby genes reveals functional specialization and disease associations in peripheral blood. [PDF]

Comput Struct Biotechnol J
Muley VY, Delahaye-Duriez A.
europepmc   +1 more source

DNA-directed termination of mammalian RNA polymerase II. [PDF]

Genes Dev
Davidson L, Rouvière JO, Sousa-Luís R, Nojima T, Proudfoot NJ, Jensen TH, West S.   +6 more
europepmc   +1 more source

Start, stop, resume, and proceed: ZmSSRP1 mediates the progression of RNA polymerase II and kernel development in maize. [PDF]

Plant Cell
Lorenzo CD.
europepmc   +1 more source

Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis. [PDF]

Nat Commun
Kujirai T, Kato J, Yamamoto K, Hirai S, Fujii T, Maehara K, Harada A, Negishi L, Ogasawara M, Yamaguchi Y, Ohkawa Y, Takizawa Y, Kurumizaka H.   +12 more
europepmc   +1 more source

Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation

Olthof AM, Noe Gonzalez MJ, Poulsen NB, Moreno NN, Bautu T, Cugusi S, Svejstrup JQ.   +6 more
europepmc   +1 more source