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Transcription elongation by RNA polymerase II
Current Opinion in Genetics & Development, 2003The elongation of transcripts by RNA polymerase II (RNAPII) is subject to regulation and requires the services of a host of accessory proteins. Although the biochemical mechanisms underlying elongation and its regulation remain obscure, recent progress sets the stage for rapid advancement in our understanding of this phase of transcription.
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RNA polymerase II transcription cycles
Current Opinion in Genetics & Development, 1993RNA polymerase II interacts with transcription factors to initiate the synthesis of mRNA. These interactions are cyclic, involving multiple RNA polymerase subunits and general transcription factors. Phosphorylation of the RNA polymerase II carboxyl-terminal domain may regulate these interactions.
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Activation of RNA polymerase II transcription
Current Opinion in Cell Biology, 1999Multiple alternative interactions between activators and co-activators stimulate transcription by RNA polymerase II. In the past two years, multiprotein co-activator complexes have been characterized and their subunits defined. TATA-box binding protein associated factor (TAF) subunits of yeast TFIID were found to be generally required for transcription
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Transcription by RNA Polymerase II
1984Gene expression in eukaryotic cells is often regulated at the level of transcription of the gene (see Darnell, 1982). In order to understand viral growth, the response of cells to external stimuli, and the processes of differentiation and development, it is of importance to understand what controls the initiation of transcription at a gene.
Ulla Hansen, Phillip A. Sharp
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2013
Structures of yeast RNA polymerase II, alone and in the act of transcription with associated DNA and RNA, have been determined to near-atomic resolution. The structures illuminate the basis for the fidelity of transcription, for translocation on the DNA template, and for release of the product RNA.
David A. Bushnell, Roger D. Kornberg
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Structures of yeast RNA polymerase II, alone and in the act of transcription with associated DNA and RNA, have been determined to near-atomic resolution. The structures illuminate the basis for the fidelity of transcription, for translocation on the DNA template, and for release of the product RNA.
David A. Bushnell, Roger D. Kornberg
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Causes and Consequences of RNA Polymerase II Stalling During Transcript Elongation
Nature Reviews Molecular Cell Biology, 2021Melvin Noe Gonzalez +2 more
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Basic Principles of Noncoding RNAs in Epigenetics
Medical Epigenetics, 2016Grazisa Rossetti, Massimiliano Pagani
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