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RNA polymerase II transcription cycles
Current Opinion in Genetics & Development, 1993RNA polymerase II interacts with transcription factors to initiate the synthesis of mRNA. These interactions are cyclic, involving multiple RNA polymerase subunits and general transcription factors. Phosphorylation of the RNA polymerase II carboxyl-terminal domain may regulate these interactions.
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Dephosphorylating RNA polymerase II
Science, 2020Transcription Transcription in metazoans requires coordination of multiple factors to control the progression of polymerases and the integrity of their RNA products. Zheng et al. identified a new dual-enzyme complex called INTAC, which is composed of protein phosphatase 2A (PP2A) core enzyme and the multisubunit RNA endonuclease Integrator.
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Transcription by RNA Polymerase II
1984Gene expression in eukaryotic cells is often regulated at the level of transcription of the gene (see Darnell, 1982). In order to understand viral growth, the response of cells to external stimuli, and the processes of differentiation and development, it is of importance to understand what controls the initiation of transcription at a gene.
Ulla Hansen, Phillip A. Sharp
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RNA polymerase drives ribonucleotide excision DNA repair in E. coli
Cell, 2023Zhitai Hao +2 more
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Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase
Cell, 2020Quan Wang, Jiqin Wu, Haofeng Wang
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RNA polymerase II speed: a key player in controlling and adapting transcriptome composition
EMBO Journal, 2021Lisa Muñíz +2 more
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SPT5 stabilization of promoter-proximal RNA polymerase II
Molecular Cell, 2021Yuki Aoi +2 more
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