Results 221 to 230 of about 511,960 (264)

Regulation of RNA polymerase II transcription

Current Opinion in Cell Biology, 1993
Transcription initiation plays a central role in the regulation of gene expression. Exciting developments in the last year have furthered our understanding of the interactions between general transcription factors and how these factors respond to modulators of transcription.
R, Drapkin, A, Merino, D, Reinberg
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The Catalytic Mechanism of RNA Polymerase II

Journal of Chemical Theory and Computation, 2011
Eukaryotic RNA polymerase II (RNAP II) transcribes the DNA into mRNA. The presence of two metal ions (usually Mg(2+)) and conserved aspartate residues in the active sites of all nucleic acid polymerases led to the adoption of a universal catalytic mechanism, known as the "two metal ion catalysis".
Alexandra T P, Carvalho, Pedro A, Fernandes, Maria J, Ramos   +2 more
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Transcript Elongation by RNA Polymerase II

Annual Review of Biochemistry, 2010
Until recently, it was generally assumed that essentially all regulation of transcription takes place via regions adjacent to the coding region of a gene—namely promoters and enhancers—and that, after recruitment to the promoter, the polymerase simply behaves like a machine, quickly “reading the gene.” However, over the past decade a revolution in ...
Selth, L., Sigurdsson, S., Svejstrup, J.
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The RNA Polymerase II Core Promoter

Annual Review of Biochemistry, 2003
▪ Abstract  The events leading to transcription of eukaryotic protein-coding genes culminate in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which can extend ∼35 bp upstream and/or downstream of this site, plays a central role in regulating initiation.
Stephen T, Smale, James T, Kadonaga
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Transcription elongation by RNA polymerase II

Current Opinion in Genetics & Development, 2003
The elongation of transcripts by RNA polymerase II (RNAPII) is subject to regulation and requires the services of a host of accessory proteins. Although the biochemical mechanisms underlying elongation and its regulation remain obscure, recent progress sets the stage for rapid advancement in our understanding of this phase of transcription.
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Promoter escape by RNA polymerase II

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002
Transcription of protein-coding genes is one of the most fundamental processes that underlies all life and is a primary mechanism of biological regulation. In eukaryotic cells, transcription depends on the formation of a complex at the promoter region of the gene that minimally includes RNA polymerase II and several auxiliary proteins known as the ...
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Initiation of transcription by RNA polymerase II

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1989
La structure des promoteurs de classe II, les facteurs operant via les elements promoteurs TATA box et le site CAP, les proteines se liant a la RNApolymerase II, la transcription a partir des promoteurs ne contenant pas de sequence TATA et les facteurs specifiques de transcription ont ete decrits dans cette ...
F H, Mermelstein, O, Flores, D, Reinberg
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Control of elongation by RNA polymerase II

Trends in Biochemical Sciences, 2000
The elongation stage of eukaryotic mRNA synthesis can be regulated by transcription factors that interact directly with the RNA polymerase II (pol II) elongation complex and by activities that modulate the structure of its chromatin template. Recent studies have revealed new elongation factors and have implicated the general initiation factors TFIIE ...
J W, Conaway, A, Shilatifard, A, Dvir, R C, Conaway   +3 more
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Advances in RNA polymerase II transcription

Current Biology, 1992
Multiple protein factors are necessary to mediate transcription by RNA polymerase II. Recently, a number of advances have been made in our understanding of how general transcription factors collectively modulate basal transcription in the context of different promoter environments and how this process is activated and repressed by accessory components.
L, Zawel, D, Reinberg
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Activation of RNA polymerase II transcription

Current Opinion in Cell Biology, 1999
Multiple alternative interactions between activators and co-activators stimulate transcription by RNA polymerase II. In the past two years, multiprotein co-activator complexes have been characterized and their subunits defined. TATA-box binding protein associated factor (TAF) subunits of yeast TFIID were found to be generally required for transcription
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