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Regulation of RNA polymerase II transcription
Current Opinion in Cell Biology, 1993Transcription initiation plays a central role in the regulation of gene expression. Exciting developments in the last year have furthered our understanding of the interactions between general transcription factors and how these factors respond to modulators of transcription.
R, Drapkin, A, Merino, D, Reinberg
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Trends in Biochemical Sciences, 1990
Eukaryotic RNA polymerase II contains two distinct structural domains: a catalytic core consisting of subunits that are homologous to other multisubunit RNA polymerases, and a unique extension of the carboxy-terminus of the largest subunit comprising tandem repeats of the seven amino acid sequence YSPTSPS. This repetitive 'tail' domain is essential for
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Eukaryotic RNA polymerase II contains two distinct structural domains: a catalytic core consisting of subunits that are homologous to other multisubunit RNA polymerases, and a unique extension of the carboxy-terminus of the largest subunit comprising tandem repeats of the seven amino acid sequence YSPTSPS. This repetitive 'tail' domain is essential for
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Transcript Elongation by RNA Polymerase II
Annual Review of Biochemistry, 2010Until recently, it was generally assumed that essentially all regulation of transcription takes place via regions adjacent to the coding region of a gene—namely promoters and enhancers—and that, after recruitment to the promoter, the polymerase simply behaves like a machine, quickly “reading the gene.” However, over the past decade a revolution in ...
Selth, L., Sigurdsson, S., Svejstrup, J.
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The RNA Polymerase II Core Promoter
Annual Review of Biochemistry, 2003▪ Abstract The events leading to transcription of eukaryotic protein-coding genes culminate in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which can extend ∼35 bp upstream and/or downstream of this site, plays a central role in regulating initiation.
Stephen T, Smale, James T, Kadonaga
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The Catalytic Mechanism of RNA Polymerase II
Journal of Chemical Theory and Computation, 2011Eukaryotic RNA polymerase II (RNAP II) transcribes the DNA into mRNA. The presence of two metal ions (usually Mg(2+)) and conserved aspartate residues in the active sites of all nucleic acid polymerases led to the adoption of a universal catalytic mechanism, known as the "two metal ion catalysis".
Alexandra T P, Carvalho +2 more
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Control of elongation by RNA polymerase II
Trends in Biochemical Sciences, 2000The elongation stage of eukaryotic mRNA synthesis can be regulated by transcription factors that interact directly with the RNA polymerase II (pol II) elongation complex and by activities that modulate the structure of its chromatin template. Recent studies have revealed new elongation factors and have implicated the general initiation factors TFIIE ...
J W, Conaway +3 more
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Advances in RNA polymerase II transcription
Current Biology, 1992Multiple protein factors are necessary to mediate transcription by RNA polymerase II. Recently, a number of advances have been made in our understanding of how general transcription factors collectively modulate basal transcription in the context of different promoter environments and how this process is activated and repressed by accessory components.
L, Zawel, D, Reinberg
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Journal of Molecular Biology, 2000
Bacterial RNA polymerase and eukaryotic RNA polymerase II exhibit striking structural similarities, including similarities in overall structure, relative positions of subunits, relative positions of functional determinants, and structures and folding topologies of subunits.
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Bacterial RNA polymerase and eukaryotic RNA polymerase II exhibit striking structural similarities, including similarities in overall structure, relative positions of subunits, relative positions of functional determinants, and structures and folding topologies of subunits.
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Initiation of transcription by RNA polymerase II
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1989La structure des promoteurs de classe II, les facteurs operant via les elements promoteurs TATA box et le site CAP, les proteines se liant a la RNApolymerase II, la transcription a partir des promoteurs ne contenant pas de sequence TATA et les facteurs specifiques de transcription ont ete decrits dans cette ...
F H, Mermelstein, O, Flores, D, Reinberg
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Promoter escape by RNA polymerase II
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002Transcription of protein-coding genes is one of the most fundamental processes that underlies all life and is a primary mechanism of biological regulation. In eukaryotic cells, transcription depends on the formation of a complex at the promoter region of the gene that minimally includes RNA polymerase II and several auxiliary proteins known as the ...
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