Results 211 to 220 of about 535,527 (262)

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Accurate prediction of cohesin and RNA Polymerase II-associated chromatin interactions using convolutional neural networks. [PDF]

Nucleic Acids Res
Abbas A, Chandratre K, Liu C, Zhang MQ, Mani RS.   +4 more
europepmc   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Histone H2B monoubiquitylation regulates elongation-to-termination transition in RNA polymerase II transcription. [PDF]

Commun Biol
Bandyopadhyay T, Basu B, Parua PK.
europepmc   +1 more source

Conserved protein Seb1 that interacts with RNA polymerase II and RNA is an antipausing transcription elongation factor. [PDF]

RNA
Kuś K, Nielsen S, Zenkin N, Vasiljeva L.   +3 more
europepmc   +1 more source

Kinetic measurement of gene-specific RNA polymerase II transcription elongation rates. [PDF]

Genome Res
Liu H, Gregersen LH.
europepmc   +1 more source

Mithramycin alters EWS::FLI1 DNA binding and RNA polymerase II processivity to inhibit nascent transcription. [PDF]

Nat Commun
Kaufman R, Flores G, Boguslawski EA, Kinn-Gurzo S, Chassé M, Beddows I, Adams M, Stout MC, Gaetano L, Lopez R, Veluvolu S, Fuller A, Kitchen-Goosen SM, Tolstyka ZP, Gedminas JM, Grohar PJ.   +15 more
europepmc   +1 more source

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The Mediator of RNA polymerase II

Chromosoma, 2005
Mediator (TRAP/ARC/PC2) is a large (22-28 subunit) protein complex that binds RNA polymerase II and controls transcription from class II genes. The evolutionarily conserved core of Mediator is found in all eukaryotes. It binds RNA polymerase II and is probably critical for basal transcription but it also mediates activation and repression of ...
Erik, Blazek, Gerhard, Mittler, Michael, Meisterernst   +2 more
openaire   +2 more sources

The RNA Polymerase II Elongation Complex

Annual Review of Biochemistry, 1995
▪ Abstract  Synthesis of eukaryotic mRNA by RNA polymerase II is an elaborate biochemical process that requires the concerted action of a large set of transcription factors. RNA polymerase II transcription proceeds through multiple stages designated preinitiation, initiation, and elongation.
T, Aso, J W, Conaway, R C, Conaway
openaire   +3 more sources