Results 191 to 200 of about 513,805 (262)

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Direct recruitment of RNA Polymerase II by NANOG to activated target genes

Mullin NP, Barbieri E, Zhang J, Vojtek M, McGarvey A, Colby D, Tomlinson S, Chambers IP.   +7 more
europepmc   +1 more source

SARS-CoV-2 nonstructural protein 1 suppresses host transcription by reducing RNA polymerase II levels. [PDF]

iScience
Li J, Wang K, Wang J, Zhong C, Wang S, Peng H, Li Z.   +6 more
europepmc   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Hierarchical buffering of cellular RNA polymerase II pools maintains transcriptional homeostasis

Gillis A, Cacioppo R, Ng PQ, Li H, Hiles-Murison B, Vidaković AT, Berry S.   +6 more
europepmc   +1 more source

Profiling active RNA polymerase II transcription start sites from total RNA by capped small RNA sequencing (csRNA-seq). [PDF]

Nat Protoc
Meyer MK, Olanrewaju OJ, Montilla-Perez P, McDonald AL, Rickard EM, Telese F, Benner C, Savenkova MI, Duttke SH.   +8 more
europepmc   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Somatic mutations in angiogenesis-related pathways and RNA polymerase II activity in sporadic brain arteriovenous malformations. [PDF]

Front Neurol
Pérez-Alfayate R, García-Barberán V, Casado-Fariñas I, Hernández-Martínez D, Gómez Del Pulgar ME, Castaño-Montoya JP, Pérez-Segura P, Cabezas-Camarero S.   +7 more
europepmc   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Gene expression analysis and proximity labeling reveal post-transcriptional functions of the yeast RNA polymerase II regulator Def1. [PDF]

J Biol Chem
Akinniyi OT, Kulkarni S, Hribal MM, Keller CA, Giardine BM, Reese JC.   +5 more
europepmc   +1 more source