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Initiation of transcription by RNA polymerase II
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1989La structure des promoteurs de classe II, les facteurs operant via les elements promoteurs TATA box et le site CAP, les proteines se liant a la RNApolymerase II, la transcription a partir des promoteurs ne contenant pas de sequence TATA et les facteurs specifiques de transcription ont ete decrits dans cette ...
F H, Mermelstein, O, Flores, D, Reinberg
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Promoter escape by RNA polymerase II
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002Transcription of protein-coding genes is one of the most fundamental processes that underlies all life and is a primary mechanism of biological regulation. In eukaryotic cells, transcription depends on the formation of a complex at the promoter region of the gene that minimally includes RNA polymerase II and several auxiliary proteins known as the ...
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Control of elongation by RNA polymerase II
Trends in Biochemical Sciences, 2000The elongation stage of eukaryotic mRNA synthesis can be regulated by transcription factors that interact directly with the RNA polymerase II (pol II) elongation complex and by activities that modulate the structure of its chromatin template. Recent studies have revealed new elongation factors and have implicated the general initiation factors TFIIE ...
J W, Conaway +3 more
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Advances in RNA polymerase II transcription
Current Biology, 1992Multiple protein factors are necessary to mediate transcription by RNA polymerase II. Recently, a number of advances have been made in our understanding of how general transcription factors collectively modulate basal transcription in the context of different promoter environments and how this process is activated and repressed by accessory components.
L, Zawel, D, Reinberg
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Activation of RNA polymerase II transcription
Current Opinion in Cell Biology, 1999Multiple alternative interactions between activators and co-activators stimulate transcription by RNA polymerase II. In the past two years, multiprotein co-activator complexes have been characterized and their subunits defined. TATA-box binding protein associated factor (TAF) subunits of yeast TFIID were found to be generally required for transcription
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RNA polymerase II transcription cycles
Current Opinion in Genetics & Development, 1993RNA polymerase II interacts with transcription factors to initiate the synthesis of mRNA. These interactions are cyclic, involving multiple RNA polymerase subunits and general transcription factors. Phosphorylation of the RNA polymerase II carboxyl-terminal domain may regulate these interactions.
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Dephosphorylating RNA polymerase II
Science, 2020Transcription Transcription in metazoans requires coordination of multiple factors to control the progression of polymerases and the integrity of their RNA products. Zheng et al. identified a new dual-enzyme complex called INTAC, which is composed of protein phosphatase 2A (PP2A) core enzyme and the multisubunit RNA endonuclease Integrator.
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Transcription by RNA Polymerase II
1984Gene expression in eukaryotic cells is often regulated at the level of transcription of the gene (see Darnell, 1982). In order to understand viral growth, the response of cells to external stimuli, and the processes of differentiation and development, it is of importance to understand what controls the initiation of transcription at a gene.
Ulla Hansen, Phillip A. Sharp
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