Results 111 to 120 of about 616,337 (352)

Molecular probes for the identification of avian Haemoproteus and Leucocytozoon parasites in tissue sections by chromogenic in situ hybridization

Parasites & Vectors, 2019
Background Avian haemosporidian parasites can cause severe disease in their hosts due to excessive exo-erythrocytic merogony and anaemia caused by blood stages.
Tanja Himmel, Josef Harl, Anna Kübber-Heiss, Cornelia Konicek, Nuhacet Fernández, Carles Juan-Sallés, Mikas Ilgūnas, Gediminas Valkiūnas, Herbert Weissenböck   +8 more
doaj   +1 more source

Patterns of gene expression in schistosomes: localization by whole mount in situ hybridization [PDF]

, 2007
rom the identification of genes to the characterization of their functions and interactions. Developmental biologists have long used whole mount in situ hybridization (WISH) to determine gene expression patterns, as a vital tool for formulating and ...
Davis, G. P. DILLON, H. V. ISAACS, J. C. ILLES, Pownall, R. A. WILSON, Skelly, Wilson   +7 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Fluorogenic Covalent Probes for RNA. [PDF]

J Am Chem Soc
ABSTRACT Sequence-generalized fluorescent labels and stains for RNA can enable imaging, tracking and analysis of the biopolymer. However, current non-covalent RNA dyes are poorly selective for RNA over DNA, interact weakly with their target, and can show limited utility in cellular RNA staining due to poor selectivity and high background ...
Shin J, Kim MJ, Kool ET.
europepmc   +2 more sources

A specific group of genes respond to cold dehydration stress in cut Alstroemeria flowers whereas ambient dehydration stress accelerates developmental senescence expression patterns [PDF]

, 2010
Petal development and senescence entails a normally irreversible process. It starts with petal expansion and pigment production, and ends with nutrient remobilization and ultimately cell death.
Aharoni, Andersen, Andersson, Basset, Breeze, Brian Thomas, Buchanan-Wollaston, Buchanan-Wollaston, Carol Wagstaff, Chanasut, Channelière, Courtney, Doi, Dudareva, Elizabeth Harrison, Emily Breeze, Eulgem, Fang, Faragher, Ferrante, Fujita, Gibbings, Gombert, Guo, Hall, Hilary Rogers, Hoeberichts, Holton, Hong, Hsiao, Huang, Irene Bramke, Jung, Khodakovskaya, Langston, Le Page-Degivry, Lee, Leverentz, Lim, Lin, Meyer, Mizoguchi, Moyle, Munne-Bosch, Nakashima, Oono, Oono, Panavas, Price, Primack, Rabbani, Ranwala, Ranwala, Reddy, Reid, Roberts, Roca, Rogers, Ross, Rudnicki, Sarah Thornber, Shinozaki, Singh, Takahashi, Tony Stead, van der Krol, van Doorn, van Doorn, Vicky Buchanan-Wollaston, Wagstaff, Wagstaff, Wagstaff, Wagstaff, Wagstaff, Weaver, Zhu   +75 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The electronic tree of life (eToL): a net of long probes to characterize the microbiome from RNA-seq data [PDF]

, 2022
Xinyue Hu, Jürgen Haas, Richard Lathe
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

NF-{kappa}B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [PDF]

, 2006
Activation of mammalian innate and acquired immune responses must be tightly regulated by elaborate mechanisms to control their onset and termination. MicroRNAs have been implicated as negative regulators controlling diverse biological processes at the ...
Baltimore, David, Boldin, Mark P., Chang, Kuang-Jung, Taganov, Konstantin D.   +3 more
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source