Results 241 to 250 of about 602,650 (303)

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Deciphering the RNA landscapes on mammalian cell surfaces. [PDF]

Protein Cell
Jiang X, Xu C, Yang E, Xu D, Peng Y, Han X, Si J, Shao Q, Liu Z, Chen Q, He W, He S, Xu Y, He C, Huang X, Hu L.   +15 more
europepmc   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Histone methyltransferase G9a crosstalks with H3K36 histone methyltransferases NSD3 and SETD2 to mediate gene activation. [PDF]

Front Cell Dev Biol
Shah A, Chaturvedi CP, Singh K, Katiyar S, Sharma A.   +4 more
europepmc   +1 more source

Decoding epigenetic and transcriptional landscapes: DNA methylome-transcriptome integration reveals novel drivers in 4NQO-Induced esophageal squamous cell carcinoma mouse model. [PDF]

Clin Epigenetics
Qian Y, Lin R, Liu Z, Zhang X, Lin D, Su M.   +5 more
europepmc   +1 more source

Isothermal nucleic acid amplification techniques: A comprehensive overview on their principle & applications as alternative to PCR. [PDF]

Pract Lab Med
Amare Amdiyee A, Sisay Tessema T.
europepmc   +1 more source

Spatial transcriptional profiling of CHB liver biopsies reveals an undetected population of zonally biased HBV-integrated cells. [PDF]

JHEP Rep
Mahadevan S, Ramirez R, Mehrabian H, Moon C, Mohan A, Vaquero E, Win R, Chaudhuri S, Chuang HC, Sun KH, Aggarwal A, Rao A, Li L, Fletcher SP, Balsitis S, Diehl L, Holdorf MM.   +16 more
europepmc   +1 more source

MASQ: A multiplex qPCR platform for quantitative alternative splicing analysis in clinical specimens. [PDF]

Mol Ther Nucleic Acids
Jeong H, Cho N, Park JI, Yoo HJ, Kim KK.
europepmc   +1 more source

Programmable molecular microscopy: CRISPR/Cas fluorescent probes revolutionizing spatiotemporal genomic imaging. [PDF]

Theranostics
Zhong XY, Yang YX, Xiong YF, Ye GC, Gong X, Zhong ML, He HD, Wang SG, Xia QD.   +8 more
europepmc   +1 more source