Results 121 to 130 of about 10,995,303 (306)

Synchronous visual analysis and editing of RNA sequence and secondary structure alignments using 4SALE

BMC Research Notes, 2008
Background The function of a noncoding RNA sequence is mainly determined by its secondary structure and therefore a family of noncoding RNA sequences is much more conserved on the structural level than on the sequence level. Understanding the function of
Dandekar Thomas, Müller Tobias, Seibel Philipp N, Wolf Matthias   +3 more
doaj   +1 more source

Phylogenetic analysis of the structure of RNase MRP RNA in yeasts

, 2002
RNase MRP is a ribonucleoprotein enzyme involved in processing precursor rRNA in eukaryotes. To facilitate our structure-function analysis of RNase MRP from Saccharomyces cerevisiae, we have determined the likely secondary structure of the RNA component ...
Zengel, Janice M., Lindahl, Lasse, Li, Xing, Pace, Norman, Frank, Daniel N.   +4 more
core   +1 more source

Louse (Insecta : Phthiraptera) mitochondrial 12S rRNA secondary structure is highly variable [PDF]

, 2002
Lice are ectoparasitic insects hosted by birds and mammals. Mitochondrial 12S rRNA sequences obtained from lice show considerable length variation and are very difficult to align.
Page, R.D.M., Cruickshank, R., Johnson, K.P.   +2 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

An efficient algorithm for exploring RNA branching conformations under the nearest-neighbor thermodynamic model

Algorithms for Molecular Biology
Background In the Nearest-Neighbor Thermodynamic Model, a standard approach for RNA secondary structure prediction, the energy of the multiloops is modeled using a linear entropic penalty governed by three branching parameters.
Svetlana Poznanović, Owen Cardwell, Christine Heitsch   +2 more
doaj   +1 more source

RNA Structure—A Neglected Puppet Master for the Evolution of Virus and Host Immunity

Frontiers in Immunology, 2018
The central dogma of molecular biology describes the flow of genetic information from DNA to protein via an RNA intermediate. For many years, RNA has been considered simply as a messenger relaying information between DNA and proteins.
Redmond P. Smyth, Redmond P. Smyth, Matteo Negroni, Andrew M. Lever, Andrew M. Lever, Johnson Mak, Julia C. Kenyon, Julia C. Kenyon, Julia C. Kenyon   +8 more
doaj   +1 more source

RNA-specific ribonucleotidyl transferases [PDF]

, 2007
RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W., Martin, G., W. Keller, G. Martin, Martin G, Keller W   +5 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Accurate prediction of genome-wide RNA secondary structure profile based on extreme gradient boosting

, 2020
For permissions, please e-mail: journals.permissions@oup.com Motivation: RNA secondary structure plays a vital role in fundamental cellular processes, and identification of RNA secondary structure is a key step to understand RNA functions.
Xiao, N, Rao, J, Ke, Y, Jiahua Rao, Yutong Lu, Lu, Y, Yuedong Yang, Huiying Zhao, Zhao, H, Yang, Y, Nong Xiao, Yaobin Ke   +11 more
core   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source