Results 11 to 20 of about 1,213,585 (311)
Nature, 2009 Our understanding of human biology and disease is ultimately dependent on a complete understanding of the genome and its functions. The recent application of microarray and sequencing technologies to transcriptomics has changed the simplistic view of transcriptomes to a more complicated view of genome-wide transcription where a large fraction of ...
Fatih, Ozsolak +9 more
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One-Pot Production of RNA in High Yield and Purity Through Cleaving Tandem Transcripts
Molecules, 2020 There is an increasing demand for efficient and robust production of short RNA molecules in both pharmaceutics and research. A standard method is in vitro transcription by T7 RNA polymerase.
Hannes Feyrer +3 more
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Life, 2022 The RNA world is one of the principal hypotheses to explain the emergence of living systems on the prebiotic Earth. It posits that RNA oligonucleotides acted as both carriers of information as well as catalytic molecules, promoting their own replication.
Tobias Göppel +3 more
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Quantifying the relationship between sequence and three-dimensional structure conservation in RNA
BMC Bioinformatics, 2010 Background In recent years, the number of available RNA structures has rapidly grown reflecting the increased interest on RNA biology. Similarly to the studies carried out two decades ago for proteins, which gave the fundamental grounds for developing ...
Capriotti Emidio, Marti-Renom Marc A
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Sequence-specific inhibition of small RNA function. [PDF]
PLoS Biology, 2004 Hundreds of microRNAs (miRNAs) and endogenous small interfering RNAs (siRNAs) have been identified from both plants and animals, yet little is known about their biochemical modes of action or biological functions.
György Hutvágner +3 more
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RNA Sequencing and Analysis [PDF]
Cold Spring Harbor Protocols, 2015 RNA sequencing (RNA-Seq) uses the capabilities of high-throughput sequencing methods to provide insight into the transcriptome of a cell. Compared to previous Sanger sequencing- and microarray-based methods, RNA-Seq provides far higher coverage and greater resolution of the dynamic nature of the transcriptome.
Kimberly R, Kukurba +1 more
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Circular RNAs in endometriosis analyzed through RNA sequencing and bioinformatics for expression profile [PDF]
PeerJBackground Endometriosis severely affects women’s physical and mental health; it is particularly important to find targets for the treatment and diagnosis of endometriosis.
Yan Yue, Jing Qian, Dandan Gui, Bin Lu
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Development of strategies for SNP detection in RNA-seq data: application to lymphoblastoid cell lines and evaluation using 1000 Genomes data. [PDF]
PLoS ONE, 2013 Next-generation RNA sequencing (RNA-seq) maps and analyzes transcriptomes and generates data on sequence variation in expressed genes. There are few reported studies on analysis strategies to maximize the yield of quality RNA-seq SNP data.
Emma M Quinn +7 more
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BMC Genomics, 2011 Background RNA-binding proteins (RBPs) play diverse roles in eukaryotic RNA processing. Despite their pervasive functions in coding and noncoding RNA biogenesis and regulation, elucidating the sequence specificities that define protein-RNA interactions ...
Wang Xin +5 more
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RNA Sequencing in Schizophrenia [PDF]
Bioinformatics and Biology Insights, 2015 Schizophrenia (SCZ) is a serious psychiatric disorder that affects 1% of general population and places a heavy burden worldwide. The underlying genetic mechanism of SCZ remains unknown, but studies indicate that the disease is associated with a global gene expression disturbance across many genes.
Xin Li, Shaolei Teng
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