Results 201 to 210 of about 1,213,585 (311)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

siRNADiscovery: a graph neural network for siRNA efficacy prediction via deep RNA sequence analysis. [PDF]

Brief Bioinform
Long R, Long R, Guo Z, Han D, Liu B, Yuan X, Chen G, Heng PA, Zhang L.   +8 more
europepmc   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

The guide-RNA sequence dictates the slicing kinetics and conformational dynamics of the Argonaute silencing complex. [PDF]

Mol Cell
Wang PY, Bartel DP.
europepmc   +1 more source

Modeling of RNA-seq fragment sequence bias reduces systematic errors in transcript abundance estimation

, 2016
Michael I. Love, John B. Hogenesch, Rafael A. Irizarry   +2 more
openalex   +2 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs. [PDF]

Nat Commun
Saito H, Handa Y, Chen M, Schneider-Poetsch T, Shichino Y, Takahashi M, Romo D, Yoshida M, Fürstner A, Ito T, Fukuzawa K, Iwasaki S.   +11 more
europepmc   +1 more source

RNAcentral: A vision for an international database of RNA sequences [PDF]

, 2011
Alex Bateman, Shipra Agrawal, Ewan Birney, Elspeth A. Bruford, Janusz M. Bujnicki, Guy Cochrane, James R. Cole, Marcel E. Dinger, Anton J. Enright, Paul P. Gardner, Daniel Gautheret, Sam Griffiths‐Jones, Jennifer Harrow, Javier Herrero, Ian Holmes, Hsien-Da Huang, Krystyna A. Kelly, Paul Kersey, Ana Kozomara, Todd M. Lowe, Manja Marz, Simon Moxon, Kim D. Pruitt, Tore Samuelsson, Peter F. Stadler, Albert J. Vilella, Jan-Hinnerk Vogel, Kelly P. Williams, Matt W. Wright, Christian Zwieb   +29 more
openalex   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Large-scale genotype prediction from RNA sequence data necessitates a new ethical and policy framework. [PDF]

Nat Genet
Majumder MA, Leek JT, Hansen KD, Razi A, McGuire AL.   +4 more
europepmc   +1 more source