Results 111 to 120 of about 1,733,662 (377)

Efficient cloning system for construction of gene silencing vectors in Aspergillus niger [PDF]

, 2008
An approach based on Gateway recombination technology to efficiently construct silencing vectors was developed for use in the biotechnologically important fungus Aspergillus niger. The transcription activator of xylanolytic and cellulolytic genes XlnR of
Graaff, L.H., de, Oliveira, J.M., Qin Ling, Veen, D., van der   +3 more
core   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Roles of RNA silencing in viral and non-viral plant immunity and in the crosstalk between disease resistance systems

Nature reviews. Molecular cell biology, 2022
S. López-Gomollón, D. Baulcombe
semanticscholar   +1 more source

Identification of RNA silencing components in soybean and sorghum

BMC Bioinformatics, 2014
BackgroundRNA silencing is a process triggered by 21–24 small RNAs to repress gene expression. Many organisms including plants use RNA silencing to regulate development and physiology, and to maintain genome stability. Plants possess two classes of small
Xiang Liu, T. Lu, Yongchao Dou, Bin Yu, Chi Zhang   +4 more
semanticscholar   +1 more source

Nucleotide bias of DCL and AGO in plant anti-virus gene silencing [PDF]

, 2010
Plant Dicer-like (DCL) and Argonaute (AGO) are the key enzymes involved in anti-virus post-transcriptional gene silencing (AV-PTGS). Here we show that AV-PTGS exhibited nucleotide preference by calculating a relative AV-PTGS efficiency on processing ...
Dalmay, Tamas, Ho, Thien, Huang, Linfeng, Li, Zhigang, Ohshima, Kazusato, Pallett, Denise W., Walsh, John A., Wang, Hui, Wang, Liang   +8 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Improvement of grain sorghum nutritive properties using modern genetic and biotechnological methods

Биотехнология и селекция растений, 2020
The paper presents a review of the studies on the use of genetic engineering and genome editing tools for improving nutritional properties of sorghum grain.
L.  A. Elkonin, V.  M. Panin, O.  A. Kenzhegulov, G.  A. Gerashchenkov   +3 more
doaj   +1 more source

In Planta Recognition of a Double-Stranded RNA Synthesis Protein Complex by a Potexviral RNA Silencing Suppressor[C][W][OPEN]

The Plant Cell, 2014
This work reports the detailed molecular function of TGBp1, a suppressor of RNA silencing encoded by a potexvirus. TGBp1 interacts with SGS3 and RDR6 and aggregates SGS3/RDR6 bodies in the cytoplasm, thereby inhibiting dsRNA synthesis.
Yukari Okano, H. Senshu, M. Hashimoto, Y. Neriya, O. Netsu, N. Minato, Tetsuya Yoshida, K. Maejima, K. Oshima, K. Komatsu, Y. Yamaji, S. Namba   +11 more
semanticscholar   +1 more source

Co-targeting RNA Polymerases IV and V Promotes Efficient De Novo DNA Methylation in Arabidopsis. [PDF]

, 2019
The RNA-directed DNA methylation (RdDM) pathway in plants controls gene expression via cytosine DNA methylation. The ability to manipulate RdDM would shed light on the mechanisms and applications of DNA methylation to control gene expression.
Chory, Joanne, Feng, Suhua, Gallego-Bartolomé, Javier, Gardiner, Jason, Ghoshal, Basudev, Jacobsen, Steven E, Kuo, Peggy Hsuanyu, Liu, Wanlu, Park, Soo Young, Zhao, Jenny Miao-Chi   +9 more
core   +2 more sources

Emerging connections between small RNAs and phytohormones [PDF]

, 2020
Small RNAs (sRNAs), mainly including miRNAs and siRNAs, are ubiquitous in eukaryotes. sRNAs mostly negatively regulate gene expression via (post-)transcriptional gene silencing through DNA methylation, mRNA cleavage, or translation inhibition.
Dubois, Marieke, Gonzalez Sanchez, Nathalie, Inzé, Dirk, Li, Ting   +3 more
core   +2 more sources