Results 131 to 140 of about 1,733,662 (377)

Manipulation of plant host susceptibility: an emerging role for viral movement proteins?

Frontiers in Plant Science, 2012
Viruses encode Viral Suppressors of RNA silencing (VSRs) to counteract RNA silencing, a major antiviral defense response in plants. Recent studies indicate a role of virus-derived siRNAs in manipulating the expression of specific host genes and that ...
Khalid eAmari, Khalid eAmari, Franck eVazquez, Manfred eHeinlein, Manfred eHeinlein   +4 more
doaj   +1 more source

The origin and effect of small RNA signaling in plants [PDF]

, 2012
Given their sessile condition, land plants need to integrate environmental cues rapidly and send signal throughout the organism to modify their metabolism accordingly. Small RNA (sRNA) molecules are among the messengers that plant cells use to carry such
Angel Emilio Martínez de Alba, Hervé Vaucheret, Jean-Sébastien Parent   +2 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Rice Dwarf Virus Small RNA Profiles in Rice and Leafhopper Reveal Distinct Patterns in Cross-Kingdom Hosts

Viruses, 2019
RNA silencing has evolved as a widespread antiviral strategy in many eukaryotic organisms. Antiviral RNA silencing is mediated by virus-derived small RNAs (vsiRNAs), created by the cleavage of double-stranded viral RNA substrates by Dicer (Dcr) in ...
Yu Wang, Rui Qiao, Chunhong Wei, Yi Li
doaj   +1 more source

The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing

EMBO Journal, 2013
Despite progress in mechanistic understanding of the RNA interference (RNAi) pathways, the subcellular sites of RNA silencing remain under debate. Here we show that loading of lipid‐transfected siRNAs and endogenous microRNAs (miRNA) into RISC (RNA ...
L. Stalder, Wolf Heusermann, L. Sokol, Dominic Trojer, Joël Wirz, Justin Hean, Anja Fritzsche, Florian Aeschimann, Vera Pfanzagl, Pascal Basselet, J. Weiler, Martin Hintersteiner, D. V. Morrissey, Nicole C Meisner-Kober   +13 more
semanticscholar   +1 more source

Techniques for RNA in vivo imaging in plants [PDF]

, 2014
Since the discovery of small RNAs and RNA silencing, RNA biology has taken a centre stage in cell and developmental biology. Small RNAs, but also mRNAs and other types of cellular and viral RNAs are processed at specific subcellular localizations.
Tilsner, Jens
core   +1 more source

Transposon Silencing of Small RNAs

Developmental Cell, 2011
Transposons and fragments of transposable elements make up approximately half of the human genome; mobilization of these elements can destabilize the genome and lead to disease-associated mutations. In 2003, miRNAs and siRNAs were known to silence target mRNAs, but small RNAs had not been directly linked to transposon control.
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

RH3 enhances antiviral defense by facilitating small RNA loading into Argonaute 2 at endoplasmic reticulum–chloroplast membrane contact sites

Nature Communications
While RNA silencing is crucial for plant resistance against viruses, the cellular connections between RNA silencing and antiviral responses in plants remain poorly understood.
Juan Huang, Juan Du, Yan Liu, Lu Lu, Yanzhuo Xu, Jianfei Shi, Qing Liu, Qi Li, Yang Liu, Yaqiu Chen, Meng Du, Yiming Zhao, Liangxiao Huo, Weiran Wang, Chenxi Ding, Liya Wei, Jianguo Wu, Yao-Wu Yuan, Jinfeng Chen, Ruixi Li, Feng Cui, Xiaoming Zhang   +21 more
doaj   +1 more source

Plant RNA Regulatory Network and RNA Granules in Virus Infection

Frontiers in Plant Science, 2017
Regulation of post-transcriptional gene expression on mRNA level in eukaryotic cells includes translocation, translation, translational repression, storage, mRNA decay, RNA silencing, and nonsense-mediated decay.
Kristiina Mäkinen, Andres Lõhmus, Maija Pollari   +2 more
doaj   +1 more source