Results 261 to 270 of about 1,673,511 (373)

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

Advanced Science, EarlyView.
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai   +6 more
wiley   +1 more source

RNA silencing is a key regulatory mechanism in the biocontrol fungus Clonostachys rosea-wheat interactions. [PDF]

BMC Biol
Piombo E, Vetukuri RR, Konakalla NC, Kalyandurg PB, Sundararajan P, Jensen DF, Karlsson M, Dubey M.   +7 more
europepmc   +1 more source

TYMV and TRV infect Arabidopsis thaliana by expressing weak suppressors of RNA silencing and inducing host RNASE THREE LIKE1. [PDF]

PLoS Pathog, 2023
Sehki H, Yu A, Elmayan T, Vaucheret H.
europepmc   +1 more source

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source

Potato Type I Protease Inhibitor Mediates Host Defence Against Potato Virus X Infection by Interacting With a Viral RNA Silencing Suppressor. [PDF]

Mol Plant Pathol
Shen M, Wang Y, Chen Y, Peng J, Wu G, Rao S, Wu J, Zheng H, Chen J, Yan F, Lu Y, Wu G.   +11 more
europepmc   +1 more source

A Viral Suppressor of RNA Silencing May Be Targeting a Plant Defence Pathway Involving Fibrillarin. [PDF]

Plants (Basel), 2022
Pérez-Cañamás M, Taliansky M, Hernández C.   +2 more
europepmc   +1 more source

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

, 2003
Zhen Jiang, Qiong Zhou, Kerri Ann Coleman, My Chouinard, Queta Boese, Michael Czech   +5 more
openalex   +1 more source

The RNA Interference Proteins and Vasa Locus are Involved in the Silencing of Retrotransposons in the Female Germline ofDrosophila melanogaster [PDF]

, 2004
Vasily V. Vagin, Mikhail S. Klenov, Alla Kalmykova, Anastasia D. Stolyarenko, Roman N. Kotelnikov, В. А. Гвоздев   +5 more
openalex   +1 more source

The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism

Advanced Science, EarlyView.
The SNP rs2863002 at the 11p11.2 locus, identified through GWAS, is associated with an increased risk of neuroblastoma. The rs2863002‐C allele impairs the binding of the transcription factor GATA3, resulting in upregulation of the HSD17B12 gene.
Teresa Maiorino, Marianna Avitabile, Vincenzo Aievola, Annalaura Montella, Vito A. Lasorsa, Ferdinando Bonfiglio, Mariagrazia Cantalupo, Sueva Cantalupo, Gilda Estinto, Matilde Tirelli, Martina Morini, Martina Ardito, Alessandra Eva, Vincenza Cerbone, Lucia Mauriello, Marianna Caterino, Margherita Ruoppolo, John M. Maris, Sharon J. Diskin, Achille Iolascon, Mario Capasso   +20 more
wiley   +1 more source

Citrus tristeza virus p20 suppresses antiviral RNA silencing by co-opting autophagy-related protein 8 to mediate the autophagic degradation of SGS3. [PDF]

PLoS Pathog
Zhang Y, Yang Z, Zhang Z, Wang G, Li XD, Hong N.   +5 more
europepmc   +1 more source