Results 241 to 250 of about 508,438 (349)

RNA Silencing in the Management of Dyslipidemias. [PDF]

Curr Atheroscler Rep, 2021
Henney NC, Banach M, Penson PE.
europepmc   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

A Viral RNA Silencing Suppressor Modulates Reactive Oxygen Species Levels to Induce the Autophagic Degradation of Dicer-Like and Argonaute-Like Proteins. [PDF]

Adv Sci (Weinh)
Zhai S, Pang T, Peng S, Zou S, Deng Z, Suzuki N, Kang Z, Andika IB, Sun L.   +8 more
europepmc   +1 more source

RNA silencing of GM-CSF in CAR-T cells reduces the secretion of multiple inflammatory cytokines. [PDF]

Invest New Drugs, 2023
Shang S, Chen Y, Yang X, Yang Y, Wang W, Wang Y.   +5 more
europepmc   +1 more source

Target RNA recognition drives PIWI∗ complex assembly for transposon silencing [PDF]

Júlia Portell i de Montserrat, László Tirián, Changwei Yu, Giacomo Silvestri, Ulrich Hohmann, Dominik Handler, Peter Duchek, Laura Fin, Clemens Plaschka, Julius Brennecke   +9 more
openalex   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Proteolytic control of the RNA silencing machinery. [PDF]

Plant Cell
Genschik P, Schiaffini M, Lechner E.
europepmc   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors [PDF]

, 2005
Kazuhiro Ogi, Minoru Toyota, Hiroaki Mita, Ayumi Satoh, Lisa Kashima, Yasushi Sasaki, Hiromu Suzuki, Kimishige Akino, Noriko Nishikawa, Makoto Noguchi, Yasuhisa Shinomura, Kohzoh Imai, Hiroyoshi Hiratsuka, Takashi Tokino   +13 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source