Results 231 to 240 of about 508,438 (349)

Role of RNA silencing in plant-viroid interactions and in viroid pathogenesis. [PDF]

Virus Res, 2023
Di Serio F, Owens RA, Navarro B, Serra P, Martínez de Alba ÁE, Delgado S, Carbonell A, Gago-Zachert S.   +7 more
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Antiviral RNA silencing in mammals: the importance of selecting the appropriate experimental model. [PDF]

Nucleic Acids Res
Liu X, Li Y.
europepmc   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

Optimized delivery of RNA silencing prolyl hydroxylase domain 2 for enhanced angiogenesis and osteogenesis using bioactive glass scaffolds. [PDF]

Sci Rep
Kunwong N, Wongrakpanich A, Amornphimoltham P, Dechkunakorn S, Srikhirin T, Saranpuetti C, Sritanaudomchai H.   +6 more
europepmc   +1 more source

HIF2 Inactivation and Tumor Suppression with a Tumor-Directed RNA-Silencing Drug in Mice and Humans. [PDF]

Clin Cancer Res, 2022
Ma Y, Joyce A, Brandenburg O, Saatchi F, Stevens C, Toffessi Tcheuyap V, Christie A, Do QN, Fatunde O, Macchiaroli A, Wong SC, Woolford L, Yousuf Q, Miyata J, Carrillo D, Onabolu O, McKenzie T, Mishra A, Hardy T, He W, Li D, Ivanishev A, Zhang Q, Pedrosa I, Kapur P, Schluep T, Kanner SB, Hamilton J, Brugarolas J.   +28 more
europepmc   +1 more source

Spliced‐leader RNA silencing: a novel stress‐induced mechanism in Trypanosoma brucei [PDF]

, 2007
Yaniv Lustig, Lilach Sheiner, Yaron Vagima, Hanoch Goldshmidt, Anish Das, Vivian Bellofatto, Shulamit Michaeli   +6 more
openalex   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Nucleoporins shape germ granule architecture and balance small RNA silencing pathways. [PDF]

Nat Commun
Shi K, Zhang Y, Du Z, Liu SC, Leon I, Fan X, Lee HC, Zhang D.   +7 more
europepmc   +1 more source

RNA-guided RNA silencing by an Asgard archaeal Argonaute

, 2023
Bastiaanssen C, Ugarte PB, Kim K, Feng Y, Finocchio G, Anzelon TA, Köstlbacher S, Tamarit D, Ettema TJG, Jinek M, MacRae IJ, Joo C, Swarts DC, Wu F.   +13 more
europepmc   +1 more source