Results 221 to 230 of about 508,438 (349)

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Response to "Antiviral RNA silencing in mammals: the importance of selecting the appropriate experimental model". [PDF]

Nucleic Acids Res
Svoboda P, Malik R.
europepmc   +1 more source

RNA silencing proteins and small RNAs in oomycete plant pathogens and biocontrol agents. [PDF]

Front Microbiol, 2023
Piombo E, Kelbessa BG, Sundararajan P, Whisson SC, Vetukuri RR, Dubey M.   +5 more
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Potato Virus Y NIb Multifunctional Protein Suppresses Antiviral Defense by Interacting with Several Protein Components of the RNA Silencing Pathway. [PDF]

Int J Mol Sci
Niraula PM, Howell S, Stratton CA, Moore MT, Dopler MB, Abeer MI, Gitcho MA, Fondong VN.   +7 more
europepmc   +1 more source

ER-associated RNA silencing promotes ER quality control. [PDF]

Nat Cell Biol, 2022
Efstathiou S, Ottens F, Schütter LS, Ravanelli S, Charmpilas N, Gutschmidt A, Le Pen J, Gehring NH, Miska EA, Bouças J, Hoppe T.   +10 more
europepmc   +1 more source

An RNA degradation complex required for silencing of Polycomb target genes [PDF]

, 2019
Haining Zhou, Gergana Shipkovenska, Marian Kalocsay, Jiuchun Zhang, Zhenhua Luo, Steven P. Gygi, Danesh Moazed   +6 more
openalex   +1 more source

Supplementary table 1 from Long Noncoding RNA ANRIL Promotes Non–Small Cell Lung Cancer Cell Proliferation and Inhibits Apoptosis by Silencing KLF2 and P21 Expression

, 2023
Fengqi Nie, Ming Sun, Jinsong Yang, Min Xie, Tongpeng Xu, Rui Xia, Yan-wen Liu, Xiang-hua Liu, Erbao Zhang, Kaihua Lu, Yongqian Shu   +10 more
openalex   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Areca palm velarivirus 1 encoded CP suppresses antiviral RNA silencing by mediating the autophagic degradation of SGS3 and disrupting the SGS3-RDR6 interaction. [PDF]

Stress Biol
Wen J, Li H, Li Z, Wang H, Cao X, Huang X.   +5 more
europepmc   +1 more source