Results 31 to 40 of about 1,733,662 (377)

Transfer RNA-derived small RNAs in the cancer transcriptome [PDF]

, 2016
The cellular lifetime includes stages such as differentiation, proliferation, division, senescence and apoptosis.These stages are driven by a strictly ordered process of transcription dynamics.
A Dueck, A Sobala, AE Hall, AM Burroughs, C Cole, C Fricke, D Green, D Haussecker, D Kim, Darrell Green, DM Thompson, DP Bartel, DR Rhodes, FE Nicolas, GL Hager, H Fu, H Goodarzi, I Salaverria, JM Perkel, M Ghildiyal, M Talpaz, MS Pagter de, NC Schopman, O Rechavi, P Adjibade, P Ivanov, P Kumar, P Kumar, Q Wang, R Levitz, RL Maute, S Yamasaki, SC Stearns, T Uchiumi, Tamas Dalmay, U Harms, William D. Fraser, YS Lee, Z Li   +38 more
core   +1 more source

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Inhibits RNA-Mediated Gene Silencing by Targeting Ago-2

Viruses, 2015
Porcine reproductive and respiratory syndrome virus (PRRSV) infection strongly modulates the host’s immune response. The RNA silencing pathway is an intracellular innate response to viral infections.
Jing Chen, Xibao Shi, Xiaozhuan Zhang, Li Wang, Jun Luo, Guangxu Xing, Ruiguang Deng, Hong Yang, Jinting Li, Aiping Wang, Gaiping Zhang   +10 more
doaj   +1 more source

Analysis of Tospovirus NSs Proteins in Suppression of Systemic Silencing. [PDF]

PLoS ONE, 2015
RNA silencing is a sequence-specific gene regulation mechanism that in plants also acts antiviral. In order to counteract antiviral RNA silencing, viruses have evolved RNA silencing suppressors (RSS).
Marcio Hedil, Mark G Sterken, Dryas de Ronde, Dick Lohuis, Richard Kormelink   +4 more
doaj   +1 more source

Transient expression vectors for functional genomics, quantification of promoter activity and RNA silencing in plants

Plant Methods, 2005
BackgroundWe describe novel plasmid vectors for transient gene expression using Agrobacterium, infiltrated into Nicotiana benthamiana leaves. We have generated a series of pGreenII cloning vectors that are ideally suited to transient gene expression, by ...
R. Hellens, A. Allan, E. Friel, K. Bolitho, K. Grafton, M. Templeton, Sakuntala Karunairetnam, A. Gleave, W. Laing   +8 more
semanticscholar   +1 more source

Assessment of RNAi-induced silencing in banana (Musa spp.) [PDF]

, 2015
In plants, RNA- based gene silencing mediated by small RNAs functions at the transcriptional or post-transcriptional level to negatively regulate target genes, repetitive sequences, viral RNAs and/or transposon elements.
Cammue, B.P.A., Coninck, B. de, Dang Thi Tuong Vi, Henry, I., Remy, S., Swennen, Rony L., Windelinckx, S.   +6 more
core   +1 more source

An enhanced CRISPR repressor for targeted mammalian gene regulation. [PDF]

, 2018
The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its utility.
Cecchi, Ryan J, Chan, Yingleong, Chavez, Alejandro, Church, George M, Church, George M, Collins, James J, Davidsohn, Noah, Ebrahimkhani, Mo R, Guo, Xiaoge, Kiani, Samira, Kuo, Chih-Chung, Lance-Byrne, Alissa, Lewis, Nathan E, Lim, Elaine T, Menn, David, Milanova, Denitsa, Pradhan, Swechchha, Sharma, Sumana, Tung, Angela, Tuttle, Marcelle, Yeo, Nan Cher   +20 more
core   +1 more source

Viral suppression of RNA silencing [PDF]

Science China Life Sciences, 2012
يلعب إسكات الجينات (إسكات الحمض النووي الريبي) دورًا أساسيًا في الدفاع المضاد للفيروسات في النباتات والفطريات واللافقاريات. تقوم الفيروسات بتشفير البروتينات التي تمنع إسكات الجينات لمواجهة دفاع المضيف. تم تحديد المثبطات الفيروسية لإسكات الحمض النووي الريبي (RSVs) من جميع الفيروسات النباتية تقريبًا التي تولد وبعض فيروسات الحشرات والثدييات. كشفت الدراسات
Lin Jiang, Chunhong Wei, Yang Li
openaire   +3 more sources

Analysis of Pineapple Mealybug Wilt Associated Virus -1 and -2 for Potential RNA Silencing Suppressors and Pathogenicity Factors

Viruses, 2015
Higher plants use RNA silencing to defend against viral infections. As a counter defense, plant viruses have evolved proteins that suppress RNA silencing.
Kishore K. Dey, Wayne B. Borth, Michael J. Melzer, Ming-Li Wang, John S. Hu   +4 more
doaj   +1 more source

Identification of Pns6, a putative movement protein of RRSV, as a silencing suppressor

Virology Journal, 2010
RNA silencing is a potent antiviral response in plants. As a counterdefense, most plant and some animal viruses encode RNA silencing suppressors. In this study, we showed that Pns6, a putative movement protein of Rice ragged stunt virus (RRSV), exhibited
Lin Qiying, Wu Zujian, Hu Meiqun, Cai Lijun, Wang Chunzheng, Du Zhenguo, Wu Jianguo, Li Yi, Xie Lianhui   +8 more
doaj   +1 more source

Engineering plant virus resistance: from RNA silencing to genome editing strategies

Plant Biotechnology Journal, 2019
Summary Viral diseases severely affect crop yield and quality, thereby threatening global food security. Genetic improvement of plant virus resistance is essential for sustainable agriculture. In the last decades, several modern technologies were applied
Yaling Zhao, Xin Yang, Guohui Zhou, Tong Zhang   +3 more
semanticscholar   +1 more source