Results 41 to 50 of about 367,330 (302)
Uirusu, 2008 Small RNAs play a critical role in the regulation of gene expression in diverse cellular processes. This mechanism, termed RNA silencing or RNAi, also functions as a defense mechanism against molecular parasites such as virus and transposon. Whereas RNA silencing is triggered by viral infection, viruses suppress RNA silencing to establish infection ...
MINE, Akira, OKUNO, Tetsuro
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Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing [PDF]
, 2010 We report that combining a DNA analog (2?F-ANA) with rigid RNA analogs [2?F-RNA and/or locked nucleic acid (LNA)] in siRNA duplexes can produce gene silencing agents with enhanced potency. The favored conformations of these two analogs are different, and
Alain, Tommy +9 more
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Viruses, 2018 Plant viruses encode virulence factors or RNA silencing suppressors to reprogram plant cellular processes or to fine-tune host RNA silencing-mediated defense responses.
Xiuling Yang +7 more
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Biomolecules, 2020 Barley (Hordeum vulgare L.) is an economically important crop cultivated in temperate climates all over the world. Adverse environmental factors negatively affect its survival and productivity.
Éva Hamar +9 more
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Traffic into silence: endomembranes and post‐transcriptional RNA silencing [PDF]
The EMBO Journal, 2014 microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-specific manner, resulting in mRNA deadenylation followed by exonucleolytic decay, mRNA ...
Kim, Yun Ju +2 more
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Root-Knot Nematode Parasitism Suppresses Host RNA Silencing
Molecular Plant-Microbe Interactions, 2017 Root-knot nematodes damage crops around the world by developing complex feeding sites from normal root cells of their hosts. The ability to initiate and maintain this feeding site (composed of individual “giant cells”) is essential to their parasitism ...
E. Walsh, J. M. Elmore, C. G. Taylor
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The Biochemist, 2004 There are at least three RNA silencing pathways for silencing specific genes in plants. In these pathways, silencing signals can be amplified and transmitted between cells, and may even be self-regulated by feedback mechanisms. Diverse biological roles of these pathways have been established, including defence against viruses, regulation of gene ...
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RNA Silencing in Surgical Disease [PDF]
Archives of Surgery, 2003 Each of our cells contains a complete copy of the genes required to create a whole organism. Thus, it was possible to clone Dolly from a single sheep epidermal cell, and we should be able to reconstruct a dinosaur from the genetic material buried in the mud of Jurassic Park.
Jyoti, Arya +3 more
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Factors influencing Barley Stripe Mosaic Virus-mediated gene silencing in wheat [PDF]
, 2010 Virus induced gene silencing (VIGS) is a technology that has been used primarily to target the virus genome in infected plants. However, if the virus genome carries inserts derived from the host plant, the system could be employed to target the mRNAs ...
Cakir, Cahid +3 more
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Silencing disease genes in the laboratory and the clinic [PDF]
, 2011 Synthetic nucleic acids are commonly used laboratory tools for modulating gene expression and have the potential to be widely used in the clinic. Progress towards nucleic acid drugs, however, has been slow and many challenges remain to be overcome before
Jonathan K Watts +3 more
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