Results 61 to 70 of about 508,438 (349)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Tomato Spotted Wilt Virus NSs Protein Supports Infection and Systemic Movement of a Potyvirus and Is a Symptom Determinant

Viruses, 2018
Plant viruses are inducers and targets of antiviral RNA silencing. To condition susceptibility, most plant viruses encode silencing suppressor proteins that interfere with antiviral RNA silencing.
Hernan Garcia-Ruiz, Sergio M. Gabriel Peralta, Patricia A. Harte-Maxwell   +2 more
doaj   +1 more source

A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe. [PDF]

PLoS Genetics, 2016
Epigenetic gene silencing plays a critical role in regulating gene expression and contributes to organismal development and cell fate acquisition in eukaryotes.
James Franklin Tucker, Corina Ohle, Géza Schermann, Katja Bendrin, Wei Zhang, Tamás Fischer, Ke Zhang   +6 more
doaj   +1 more source

To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]

, 2015
Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH, MacDonald, Margaret R, Rice, Charles M   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Multiple Domains of the Tobacco mosaic virus p126 Protein Can Independently Suppress Local and Systemic RNA Silencing

Molecular Plant-Microbe Interactions, 2012
Small RNA-mediated RNA silencing is a widespread antiviral mechanism in plants and other organisms. Many viruses encode suppressors of RNA silencing for counter-defense.
Li-Ya Wang, Shih-Shun Lin, Ting-Hsuan Hung, Tsai-Kun Li, Nai-Chun Lin, Tang-Long Shen   +5 more
doaj   +1 more source

Candida albicans repetitive elements display epigenetic diversity and plasticity [PDF]

, 2016
Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and whether its structure can be remodelled in response to environmental signals. Here,
A Ellahi, A Pidoux, A Selmecki, aF Straight, BD Strahl, C Ketel, C Li, C Trapnell, Ca Froyd, CJ Merrick, D Kadosh, DE Gottschling, GD Shankaranarayana, H Chibana, H Chibana, J Haran, J Huang, J Huang, J Nakayama, J Pérez-Martín, J Wendland, JC Tanny, JS Smith, Ka Morano, KR Hansen, L Vasiljeva, LH Freitas-Junior, LN Rusche, M Bryk, M Bühler, M Dubarry, M Paschini, M Van het Hoog, MA Pfaller, MD De Backer, MJ McEachern, N Saksouk, PA Dumesic, PR Lephart, PR Lephart, R Kaur, RB Wilson, RJ Bennett, S Greiss, S Henikoff, S Imai, S Kueng, S Rea, SI Iwaguchi, T Jones, T Kobayashi, T Kobayashi, T Kouzarides, VM Bruno, W Shou, WS Chu, X Bi   +56 more
core   +1 more source

Non‐cell autonomous RNA silencing [PDF]

FEBS Letters, 2005
In plants and in some animals, the effects of post‐transcriptional RNA silencing can extend beyond its sites of initiation, owing to the movement of signal molecules. Although the mechanisms and channels involved are different, plant and animal silencing signals must have RNA components that account for the nucleotide sequence‐specificity of their ...
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Supervised learning classification models for prediction of plant virus encoded RNA silencing suppressors. [PDF]

PLoS ONE, 2014
Viral encoded RNA silencing suppressor proteins interfere with the host RNA silencing machinery, facilitating viral infection by evading host immunity.
Zeenia Jagga, Dinesh Gupta
doaj   +1 more source