Results 71 to 80 of about 508,438 (349)

RNAi efficiency, systemic properties, and novel delivery methods for pest insect control : what we know so far [PDF]

, 2016
In recent years, the research on the potential of using RNA interference (RNAi) to suppress crop pests has made an outstanding growth. However, given the variability of RNAi efficiency that is observed in many insects, the development of novel approaches
Christiaens, Olivier, Joga, Mallikarjuna, Smagghe, Guy, Zotti, Moises J   +3 more
core   +2 more sources

Viral suppressors: Combatting RNA silencing [PDF]

Nature Plants, 2017
[EN] Plants defend themselves from invading viruses using RNA silencing. However, plant viruses try to spoil this defensive mechanism by expressing one or more proteins that act as RNA silencing suppressors. One such protein spoils plant defence by transporting the silencing signal into the peroxisomes to avoid its systemic spread.
openaire   +5 more sources

RNA Silencing in Surgical Disease [PDF]

Archives of Surgery, 2003
Each of our cells contains a complete copy of the genes required to create a whole organism. Thus, it was possible to clone Dolly from a single sheep epidermal cell, and we should be able to reconstruct a dinosaur from the genetic material buried in the mud of Jurassic Park.
Jyoti, Arya, John Y, Cha, Anirban, Banerjee, Alden H, Harken   +3 more
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CRP-cAMP mediates silencing of Salmonella virulence at the post-transcriptional level [PDF]

, 2018
Invasion of epithelial cells by Salmonella enterica requires expression of genes located in the pathogenicity island I (SPI-1). The expression of SPI-1 genes is very tightly regulated and activated only under specific conditions.
Balsalobre, Carlos, El Mouali, Youssef, Gaviria-Cantin, Tania, Gilbert, Marta, Sánchez Romero, María Antonia, Vogel, Jörg, Westermann, Alexander J.   +6 more
core   +4 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Banana plants use post-transcriptional gene silencing to control banana streak virus infection [PDF]

, 2013
Banana streak virus (BSV), the causative agent of banana streak disease, is a plant pararetrovirus belonging to the family Caulimoviridae, genus Badnavirus.
Chabannes, Matthieu, Duroy, Pierre-Olivier, Iskra Caruana, Marie-Line, Laboureau, Nathalie, Pooggin, Mikhail, Rajendran, Rajeswaran, Seguin, Jonathan   +6 more
core  

The role of the Cucumber mosaic virus 2b protein in viral movement and symptom induction [PDF]

, 2009
The Cucumber mosaic virus (CMV) 2b protein is a counter-defense factor and symptom determinant. Conserved domains in the 2b protein sequence were mutated in the 2b gene of strain Fny-CMV.
Chen H.-Y., Fiona C. Robertson, Ham B.-K., Heiko Ziebell, John A. Walsh, John P. Carr, Ki Hyun Ryu, Lot H., Mathew Lewsey, Monique Surette, Palukaitis P., Peter Palukaitis, Roossinck M. J., Sun Hee Choi, Tina Payne, Tomas Canto   +15 more
core   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

DICER-LIKE2 plays a primary role in transitive silencing of transgenes in Arabidopsis.

PLoS ONE, 2008
Dicer-like (DCL) enzymes play a pivotal role in RNA silencing in plants, processing the long double-stranded RNA (dsRNA) that triggers silencing into the primary short interfering RNAs (siRNAs) that mediate it.
Sizolwenkosi Mlotshwa, Gail J Pruss, Angela Peragine, Matthew W Endres, Junjie Li, Xuemei Chen, R Scott Poethig, Lewis H Bowman, Vicki Vance   +8 more
doaj   +1 more source