Results 71 to 80 of about 505,956 (331)

Viral suppressors: Combatting RNA silencing [PDF]

Nature Plants, 2017
[EN] Plants defend themselves from invading viruses using RNA silencing. However, plant viruses try to spoil this defensive mechanism by expressing one or more proteins that act as RNA silencing suppressors. One such protein spoils plant defence by transporting the silencing signal into the peroxisomes to avoid its systemic spread.
openaire   +5 more sources

RNA Silencing in Surgical Disease [PDF]

Archives of Surgery, 2003
Each of our cells contains a complete copy of the genes required to create a whole organism. Thus, it was possible to clone Dolly from a single sheep epidermal cell, and we should be able to reconstruct a dinosaur from the genetic material buried in the mud of Jurassic Park.
Jyoti, Arya, John Y, Cha, Anirban, Banerjee, Alden H, Harken   +3 more
openaire   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Efficient cloning system for construction of gene silencing vectors in Aspergillus niger [PDF]

, 2008
An approach based on Gateway recombination technology to efficiently construct silencing vectors was developed for use in the biotechnologically important fungus Aspergillus niger. The transcription activator of xylanolytic and cellulolytic genes XlnR of
Graaff, L.H., de, Oliveira, J.M., Qin Ling, Veen, D., van der   +3 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Effect of Non-Coding RNA on Post-Transcriptional Gene Silencing of Alzheimer Disease [PDF]

, 2010
A large amount of hidden biological information is contained in the human genome, which is not expressed or revealed in the form of proteins; the usual end product form of gene expression.
Arun Mohan, Deepa Gopakumar, Krishnan Namboori, Premkumar P, Radhagayathri K.U., Ramachandran K.I., Varun Gopal, Vasavi C.S.   +7 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Banana plants use post-transcriptional gene silencing to control banana streak virus infection [PDF]

, 2013
Banana streak virus (BSV), the causative agent of banana streak disease, is a plant pararetrovirus belonging to the family Caulimoviridae, genus Badnavirus.
Chabannes, Matthieu, Duroy, Pierre-Olivier, Iskra Caruana, Marie-Line, Laboureau, Nathalie, Pooggin, Mikhail, Rajendran, Rajeswaran, Seguin, Jonathan   +6 more
core  

Viral suppression of RNA silencing [PDF]

Science China Life Sciences, 2012
يلعب إسكات الجينات (إسكات الحمض النووي الريبي) دورًا أساسيًا في الدفاع المضاد للفيروسات في النباتات والفطريات واللافقاريات. تقوم الفيروسات بتشفير البروتينات التي تمنع إسكات الجينات لمواجهة دفاع المضيف. تم تحديد المثبطات الفيروسية لإسكات الحمض النووي الريبي (RSVs) من جميع الفيروسات النباتية تقريبًا التي تولد وبعض فيروسات الحشرات والثدييات. كشفت الدراسات
Lin Jiang, Chunhong Wei, Yang Li
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source