Results 121 to 130 of about 544,829 (251)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Low RNA stability signifies increased post-transcriptional regulation of cell identity genes. [PDF]

Nucleic Acids Res, 2023
Li Y, Yi Y, Lv J, Gao X, Yu Y, Babu SS, Bruno I, Zhao D, Xia B, Peng W, Zhu J, Chen H, Zhang L, Cao Q, Chen K.   +14 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

ADAR1 and ADAR2 associate with the RNA exosome and modulate RNA stability. [PDF]

Nucleic Acids Res
Vukić D, Du Q, Cherian A, Amoruso D, Brožinová K, Wacheul L, Lacovich V, Zorbas C, Yadav L, Sedmík J, Keskitalo S, Hajji K, Stejskal S, Varjosalo M, Lafontaine DLJ, Keegan LP, O'Connell MA.   +16 more
europepmc   +1 more source

Role of the 5' end phosphorylation state for small RNA stability and target RNA regulation in bacteria. [PDF]

Nucleic Acids Res, 2023
Schilder A, Görke B.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Evolutionary refinement of the ZIKV 5' UTR dictates a trade-off between RNA stability and promoter accessibility. [PDF]

NAR Mol Med
Wang AB, Abram QH, Camargo C, Barnard TR, Sagan SM.   +4 more
europepmc   +1 more source

Author Correction: RNA stability controlled by m⁶A methylation contributes to X-to-autosome dosage compensation in mammals. [PDF]

Nat Struct Mol Biol, 2023
Rücklé C, Körtel N, Basilicata MF, Busch A, Zhou Y, Hoch-Kraft P, Tretow K, Kielisch F, Bertin M, Pradhan M, Musheev M, Schweiger S, Niehrs C, Rausch O, Zarnack K, Keller Valsecchi CI, König J.   +16 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Buc Maintains Maternal RNA Stability and Embryogenesis in Zebrafish. [PDF]

Cells
Miao R, Xie Y, Han Q, Meng Y, Tang Q, Mei J, Ren F.   +6 more
europepmc   +1 more source